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Structure and assembly of membrane proteins at tight junctions
Vecchio, A. (PI)
National Institute of General Medical Sciences
08/1/23 → 08/31/25
Project: Research
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Biophysical basis of tight junction barrier modulation by a pan-claudin-binding molecule
Ogbu, C. P., De Las Alas, M., Mandriota, A. M., Liu, X., Kapoor, S., Choudhury, J., Ruma, Y. N., Goodman, M. C., Sanders, C. R., Gonen, T., Kossiakoff, A. A., Duffey, M. E. & Vecchio, A. J., Jun 1 2025, In: PNAS Nexus. 4, 6, pgaf189.Research output: Contribution to journal › Article › peer-review
Open Access3 Scopus citations -
One-shot design of functional protein binders with BindCraft
Pacesa, M., Nickel, L., Schellhaas, C., Schmidt, J., Pyatova, E., Kissling, L., Barendse, P., Choudhury, J., Kapoor, S., Alcaraz-Serna, A., Cho, Y., Ghamary, K. H., Vinué, L., Yachnin, B. J., Wollacott, A. M., Buckley, S., Westphal, A. H., Lindhoud, S., Georgeon, S. & Goverde, C. A. & 9 others, , Oct 9 2025, In: Nature. 646, 8084, p. 483-492 10 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Scopus citations -
Structures of a synthetic antibody selected against and bound to the C-terminal domain of Clostridium perfringens enterotoxin
Ogbu, C. P., Goldbach, N. M., Pacesa, M., Kapoor, S., Correia, B. E. & Vecchio, A. J., Oct 2025, In: Protein Science. 34, 10, e70281.Research output: Contribution to journal › Article › peer-review
Open Access -
Computational design of soluble and functional membrane protein analogues
Goverde, C. A., Pacesa, M., Goldbach, N., Dornfeld, L. J., Balbi, P. E. M., Georgeon, S., Rosset, S., Kapoor, S., Choudhury, J., Dauparas, J., Schellhaas, C., Kozlov, S., Baker, D., Ovchinnikov, S., Vecchio, A. J. & Correia, B. E., Jul 11 2024, In: Nature. 631, 8020, p. 449-458 10 p.Research output: Contribution to journal › Article › peer-review
Open Access65 Scopus citations -
Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4
Rathnayake, S. S., Erramilli, S. K., Kossiakoff, A. A. & Vecchio, A. J., Nov 7 2024, In: Structure. 32, 11, p. 1936-1951.e5Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations