Lejuez's research focuses on the use of basic laboratory research findings for the development of behavioral interventions to address a wide range of psychological conditions including mood disorders, addictions, and personality disorders for marginalized and underserved populations. At Maryland, he founded and led the Center for Addictions, Personality and Emotions Research. Lejuez has received grant funding from several sources for his research and is widely published, having also served on several editorial boards and having been a founding editor of the publication "Personality Disorders: Theory, Research and Treatment." Moreover, he is the co-editor of the "Cambridge University Press Handbook of Personality Disorders," published in spring 2020 and currently has a contract with Oxford University Press for a book about transdiagnostic behavioral therapy he has developed to be part of their "Treatments at Work" series.