Reflex and central neural control of cardiovascular and respiratory function.

The overall goal of the research in my laboratory is to understand the mechanisms by which central nervous system (CNS) neurons integrate peripheral and central inputs in respiratory and cardiovascular control. At present, we are investigating CNS sites and neuropharmacological mechanisms mediating hypoxic ventilatory and sympathetic responses. Severe brain hypoxia which may result from numerous cardiovascular and respiratory diseases (e.g., stroke, cor pulmonale) results in a shift from respiratory depression to excitation (gasping) and an increase in sympathetic output. In the laboratory, we are examining the brainstem sites and neural mechanism(s) responsible for this shift in respiratory patterning as well as the synchronization of the central respiratory cycle with sympathetic activity. The experimental approach in the laboratory involves neuroanatomical mapping, electrophysiological recording, and neuropharmacology. Another focus of research in my laboratory examines reflex and central neural control of the airways.