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Collaborations and top research areas from the last five years
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Development of ASO-RiboTAC System as a Potential Therapeutic for Myotonic Dystrophy (Amy Mascorro MDF Fellowship YR1)
Sheng, J. (PI), Berglund, A. (CoI) & Mascorro, A. (CoI)
01/1/26 → 12/31/26
Project: Research
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Development of Photoswitchable Nucleotides to Control RNA Biochemistry
Sheng, J. (PI) & Wang, T. (CoPI)
09/1/25 → 08/31/28
Project: Research
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Optimizing Enhanced Hammerhead Ribozymes for Retinal Nucleic Acid Therapeutics
Halvorsen, K. (CoI), Sheng, J. (CoI), Vangaveti, S. (CoI), Sullivan, J. (PI) & Farkas, M. (CoI)
08/1/23 → 04/30/27
Project: Research
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Chemical Modifications to Wobble Uridines in tRNA Regulate Responses to Stress
Sheng, J. (PI), Begley, T. (CoPI), Lin, Q. (CoI) & Vangaveti, S. (CoI)
National Institute of General Medical Sciences
07/8/22 → 04/30/27
Project: Research
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MRI: Acquisition of a Trapped Ion Mobility Spectrometer Quadrupole Time-of-Flight (TIMS-QTOF) with MALDI for Multidisciplinary Research and Education
Liang, Y. (PI), Sheng, J. (CoPI), Valm, A. (CoPI), Bari, M. A. (CoI), Begley, T. (CoI) & Berglund, A. (CoI)
10/1/22 → 09/30/25
Project: Research
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A Geranylated Natural Product Simamycin Disrupts the Allosteric Catalysis of tRNA-2-selenouridine Synthase SelU
Dansereau, S. J., Shekhtman, A., Epifano, F., Genovese, S., Fiorito, S., Begley, T. J. & Sheng, J., Jun 17 2025, In: Biochemistry. 64, 12, p. 2640-2648 9 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
An Oxyprenylated Phenylpropanoid Pharmacologic Scaffold for SelU Inhibition
Dansereau, S. J., Shekhtman, A., Genovese, S., Collevecchio, C., Fiorito, S., Begley, T. J., Epifano, F. & Sheng, J., Aug 22 2025, In: ChemBioChem. 26, 15, e202500280.Research output: Contribution to journal › Article › peer-review
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Designing Reversible Photoswitching Azobenzene-Modified Nucleotide for Controlling Biological Function
Li, J., Du, J., He, W., Adelakun, I. O., Zhong, M., Boyer, S., Zheng, Y. Y., Lin, Q., Kirmizialtin, S., Sheng, J. & Wang, T., Jun 25 2025, In: Journal of the American Chemical Society. 147, 25, p. 21638-21648 11 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
Heavy Chalcogen Properties of Sulfur and Selenium Enhance Nucleic Acid-Based Therapeutics
Dansereau, S. J. & Sheng, J., Feb 2025, In: Biomolecules. 15, 2, 218.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
Nature-Inspired Chemical Probes for Labeling tRNAs Containing 2-Thiouridine (s2U)
Zhou, H., Li, Y., Zhang, J., Wang, L., Zheng, Y. Y., Wu, C., Begley, T. J., Sheng, J. & Wang, R., Nov 8 2025, In: ChemBioChem. 26, 21, e202500453.Research output: Contribution to journal › Article › peer-review