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Defining molecular mechanisms underlying hyperkeratosis of pachyonychia congenita in a mouse model expressing a mutant of KRT6A
Chen, J. (PI) & Josephs, E. (CoPI)
Pachyonychia Congenita Project
01/1/26 → 12/31/26
Project: Research
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Research Seed Grant Program
Zhou, C. (CoI), Lacy, D. (CoI), Park, J. (CoI), Beverley, J. (CoI), Paul, M. (CoI), Shin, D. (CoI), Watson, D. (CoI), Jarvis, J. (CoI), Shin, S. (CoI), Tripp, J. (CoI), Ford Versypt, A. (CoI), Smith, B. (CoI), Faghihi, D. (CoI), Aga, D. (CoI), Subryan, H. (CoI), Xu, W. (CoI), Lao, Y.-H. (CoI), Cavuoto, L. (CoI), Sisto, S. (CoI), Chen, H.-Y. (CoI), Sun, Y. (CoI), Liu, X. (CoI), Halterman, M. (CoI), Orom, H. (CoI), Meyer, P. (CoI), Gokcumen, O. (CoI), Cook, T. (CoI), Ferkey, D. (CoI), Alexander, J. (CoI), Atilla-Gokcumen, G. (CoI), Almas, B. (PI), Iacabucci, J. (PI), Agrawal, S. (CoI), Boivin, B. (CoI), Boon, E. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Chakraborty, N. (CoI), Chen, J. (CoI), Choi, S. (CoI), Citovsky, V. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Feinberg, E. (CoI), Feldblyum, J. (CoI), Fries, B. (CoI), Guo, H. (CoI), Hamideh, S. (CoI), Henkes, G. A. (CoI), Huang, R. (CoI), Talos, F. M. (CoI), Ke, C. (CoI), Kim, H. (CoI), Lapenis, A. (CoI), Lee, J. U. (CoI), Leighton, G. (CoI), Leung, H. C. (CoI), Liu, H. (CoI), Loh, S. (CoI), Luo, J. (CoI), Mofakham, S. (CoI), Mueller, K. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Pisconti, D. (CoI), Razavi Aghjeh, M. J. (CoI), Salman, E. (CoI), Scimemi, A. (CoI), Shelly, M. (CoI), Siegel, P. (CoI), Sirotkin, H. I. (CoI), Tumey, L. (CoI), Wang, Y. (CoI), Agrawal, S. (CoI), Boon, E. (CoI), Chakraborty, N. (CoI), Chen, J. (CoI), Citovsky, V. (CoI), Feinberg, E. (CoI), Fries, B. (CoI), Hamideh, S. (CoI), Henkes, G. (CoI), Ionas, F. (CoI), Kim, H. (CoI), Leung, H.-C. (CoI), Loh, S. (CoI), Luo, J. (CoI), Mofakham, S. (CoI), Mueller, K. (CoI), Pisconti, A. (CoI), Salman, E. (CoI), Shelly, M. (CoI), Sirotkin, H. (CoI), Loh, S. (CoI), Luo, J. (CoI), Almas, B. (PI), Iacabucci, J. (PI), Aga, D. (CoI), Agrawal, S. (CoI), Alexander, J. (CoI), Atilla-Gokcumen, G. (CoI), Beverley, J. (CoI), Boivin, B. (CoI), Boon, E. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Cavuoto, L. (CoI), Tran, S. (CoI), Chen, H.-Y. (CoI), Chen, J. (CoI), Choi, S. (CoI), Citovsky, V. (CoI), Cook, T. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Faghihi, D. (CoI), Feinberg, E. (CoI), Feldblyum, J. (CoI), Ferkey, D. (CoI), Ford Versypt, A. (CoI), Fries, B. (CoI), Gokcumen, O. (CoI), Guo, H. (CoI), Halterman, M. (CoI), Halterman, M. (CoI), Hamideh, S. (CoI), Henkes, G. (CoI), Huang, R. (CoI), Ionas, F. (CoI), Jarvis, J. (CoI), Ke, C. (CoI), Kim, H. (CoI), Lacy, D. (CoI), Lao, Y.-H. S. (CoI), Lapenis, A. (CoI), Lee, J. U. (CoI), Leighton, G. (CoI), Leung, H.-C. (CoI), Liu, H. (CoI), Liu, X. (CoI), Meyer, P. (CoI), Mofakham, S. (CoI), Mueller, K. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Orom, H. (CoI), Park, J. (CoI), Paul, M. (CoI), Pisconti, A. (CoI), Razavi Aghjeh, M. J. (CoI), Salman, E. (CoI), Scimemi, A. (CoI), Shelly, M. (CoI), Shin, D. (CoI), Shin, S. (CoI), Siegel, P. (CoI), Sirotkin, H. (CoI), Sisto, S. A. (CoI), Smith, B. (CoI), Subryan, H. (CoI), Sun, Y. (CoI), Tripp, J. (CoI), Tumey, L. (CoI), Wang, Y. (CoI), Watson, D. (CoI), Xu, W. (CoI), Zhou, C. (CoI), Agrawal, S. (CoI), Boon, E. (CoI), Chakraborty, N. (CoI), Chen, J. (CoI), Citovsky, V. (CoI), Feinberg, E. (CoI), Fries, B. (CoI), Hamideh, S. (CoI), Henkes, G. A. (CoI), Talos, F. M. (CoI), Kim, H. (CoI), Leung, H. C. (CoI), Mofakham, S. (CoI), Mueller, K. (CoI), Pisconti, D. (CoI), Salman, E. (CoI), Shelly, M. (CoI), Sirotkin, H. I. (CoI), Almas, B. (PI), Iacabucci, J. (PI), Aga, D. (CoI), Alexander, J. (CoI), Atilla-Gokcumen, G. (CoI), Beverley, J. (CoI), Boivin, B. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Cavuoto, L. (CoI), Chen, H.-Y. (CoI), Choi, S. (CoI), Cook, T. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Faghihi, D. (CoI), Feldblyum, J. (CoI), Ferkey, D. (CoI), Ford Versypt, A. (CoI), Gokcumen, O. (CoI), Guo, H. (CoI), Halterman, M. (CoI), Halterman, M. (CoI), Huang, R. (CoI), Jarvis, J. (CoI), Ke, C. (CoI), Lacy, D. (CoI), Lao, Y.-H. S. (CoI), Lapenis, A. (CoI), Lee, J. U. (CoI), Leighton, G. (CoI), Liu, H. (CoI), Liu, X. (CoI), Loh, S. (CoI), Luo, J. (CoI), Meyer, P. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Orom, H. (CoI), Park, J. (CoI), Paul, M. (CoI), Razavi Aghjeh, M. J. (CoI), Scimemi, A. (CoI), Shin, D. (CoI), Shin, S. (CoI), Siegel, P. (CoI), Sisto, S. A. (CoI), Smith, B. (CoI), Subryan, H. (CoI), Sun, Y. (CoI), Tripp, J. (CoI), Tumey, L. (CoI), Wang, Y. (CoI), Watson, D. (CoI), Xu, W. (CoI), Zhou, C. (CoI), Lapenas, A. (CoI), Boivin, B. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Choi, S. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Feldblyum, J. (CoI), Guo, H. (CoI), Huang, R. (CoI), Ke, C. (CoI), Lee, J. U. (CoI), Liu, H. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Razavi Aghjeh, M. J. (CoI), Scimemi, A. (CoI), Siegel, P. (CoI), Tumey, L. N. (CoI), Wang, Y. (CoI), Boivin, B. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Choi, S. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Feldblyum, J. (CoI), Guo, H. (CoI), Huang, R. (CoI), Ke, C. (CoI), Lapenas, A. (CoI), Lee, J. U. (CoI), Liu, H. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Razavi Aghjeh, M. J. (CoI), Scimemi, A. (CoI), Siegel, P. (CoI), Tumey, L. (CoI), Wang, Y. (CoI), Almas, B. (PI), Iacabucci, J. (PI), Aga, D. (CoI), Agrawal, S. (CoI), Alexander, J. (CoI), Atilla-Gokcumen, G. (CoI), Beverley, J. (CoI), Boon, E. (CoI), Cavuoto, L. (CoI), Chakraborty, N. (CoI), Catmore, J. R. (CoI), Chen, J. (CoI), Citovsky, V. (CoI), Cook, T. (CoI), Faghihi, D. (CoI), Feinberg, E. (CoI), Ferkey, D. (CoI), Ford Versypt, A. (CoI), Fries, B. (CoI), Gokcumen, O. (CoI), Halterman, M. (CoI), Halterman, M. (CoI), Hamideh, S. (CoI), Henkes, G. (CoI), Ionas, F. (CoI), Jarvis, J. (CoI), Kim, H. (CoI), Lacy, D. (CoI), Lao, Y.-H. S. (CoI), Leighton, G. (CoI), Leung, H.-C. (CoI), Liu, X. (CoI), Loh, S. (CoI), Luo, J. (CoI), Meyer, P. (CoI), Mofakham, S. (CoI), Mueller, K. (CoI), Orom, H. (CoI), Park, J. (CoI), Paul, M. (CoI), Pisconti, A. (CoI), Salman, E. (CoI), Shelly, M. (CoI), Shin, D. (CoI), Majumder, G. (CoI), Sirotkin, H. (CoI), Sisto, S. A. (CoI), Smith, B. (CoI), Subryan, H. (CoI), Sun, Y. (CoI), Sauvan, E. (CoI), Watson, D. (CoI), Xu, W. (CoI), Zhou, C. (CoI), Boivin, B. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Choi, S. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Feldblyum, J. (CoI), Guo, H. (CoI), Huang, R. (CoI), Ke, C. (CoI), Lee, J. U. (CoI), Liu, H. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Razavi Aghjeh, M. J. (CoI), Scimemi, A. (CoI), Siegel, P. (CoI), Tumey, L. N. (CoI), Wang, Y. (CoI), Boivin, B. (CoI), Brooks, T. (CoI), Callahan, B. (CoI), Choi, S. (CoI), Downs, C. (CoI), Elias Arriaga, A. L. (CoI), Feldblyum, J. (CoI), Guo, H. (CoI), Huang, R. (CoI), Ke, C. (CoI), Lee, J. U. (CoI), Liu, H. (CoI), Ning, F. (CoI), Oktyabrsky, S. (CoI), Razavi Aghjeh, M. J. (CoI), Scimemi, A. (CoI), Siegel, P. (CoI), Tumey, L. N. (CoI) & Wang, Y. (CoI)
04/1/22 → 03/31/27
University at Buffalo, Upstate Medical University, Stony Brook University, University at Albany, Binghamton University, College of Environmental Science & Forestry, Purchase College
Project: Research
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Instructive roles of mesenchymal proteoglycans in hair follicle morphogenesis and maintenance
Chen, J. (PI), Luk, E. (CoPI), Takemaru, K.-I. (CoPI) & Yang, J. (CoPI)
National Inst of Arthritis Musculoskeletal & Skin
09/3/24 → 07/31/26
Project: Research
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RPGRIP1L and PKC beta II in desmoglein internalization
Chen, J. (PI) & Choi, Y. J. (CoPI)
National Inst of Arthritis Musculoskeletal & Skin
03/1/17 → 02/29/20
Project: Research
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Identification of conserved residues essential for the ciliogenic functions of WDPCP
Choi, Y. J., Hwang, S., Lee, C., Zeng, H., Chen, X., Jo, U., Kim, H., Liu, A., Park, D., Wallingford, J. B. & Chen, J., Nov 2025, In: DMM Disease Models and Mechanisms. 18, 11, dmm052149.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations -
ΔNp63 Regulates Homeostasis, Stemness, and Suppression of Inflammation in the Adult Epidermis
Eyermann, C. E., Chen, X., Somuncu, O. S., Li, J., Joukov, A. N., Chen, J. & Alexandrova, E. M., Jan 2024, In: Journal of Investigative Dermatology. 144, 1, p. 73-83.e10Research output: Contribution to journal › Article › peer-review
Open Access14 Scopus citations -
Hair follicle dystrophy in a litter of domestic cats resembling lanceolate hair mutant mice
Rostaher, A., Bettenay, S., Specht, L., Silva, K. A., Bechtold, L., Chen, J., Majzoub, M., Mueller, R. S. & Sundberg, J. P., Feb 2021, In: Veterinary Dermatology. 32, 1, p. 74-e14Research output: Contribution to journal › Article › peer-review
4 Scopus citations -
Hair Loss Caused by Gain-of-Function Mutant TRPV3 Is Associated with Premature Differentiation of Follicular Keratinocytes
Song, Z., Chen, X., Zhao, Q., Stanic, V., Lin, Z., Yang, S., Chen, T., Chen, J. & Yang, Y., Aug 2021, In: Journal of Investigative Dermatology. 141, 8, p. 1964-1974 11 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Scopus citations -
GORAB promotes embryonic lung maturation through antagonizing AKT phosphorylation, versican expression, and mesenchymal cell migration
Liu, Y., Chen, X., Choi, Y. J., Yang, N., Song, Z., Snedecor, E. R., Liang, W., Leung, E. L. H., Zhang, L., Qin, C. & Chen, J., Apr 1 2020, In: FASEB Journal. 34, 4, p. 4918-4933 16 p.Research output: Contribution to journal › Article › peer-review
Open Access1 Scopus citations