Personal profile
Research interests
Lens membrane proteins and gap junctions.
Our research focuses on the physiology and pharmacology of mammalian lens membrane transporters, with specific emphasis on aquaporins, glucose transporters, and Vitamin C transporters and their relation to lens cataract and transparency.
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Collaborations and top research areas from the last five years
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Roles of Lens Aquaporins and GPX1 in Hydrogen Peroxide Balance, Homeostasis, and Aging
Varadaraj, K. (PI), Kumari, S. (CoPI) & Mathias, R. (CoPI)
09/1/22 → 08/31/26
Project: Research
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Role of Aquaporins in Mammalian Lens Development, Transparency and Homeostasis
Varadaraj, K. (PI) & Kumari, S. (CoPI)
12/1/15 → 11/30/21
Project: Research
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Role of Aquaporin-0 for Cell-to-Cell Adhesion and Lens Transparency
Varadaraj, K. (PI) & Kumari, S. (CoPI)
04/1/10 → 03/31/16
Project: Research
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Volume Regulation In Normal And Cataractous Lenses
Varadaraj, K. (CoPI) & Mathias, R. (PI)
07/1/05 → 08/31/10
Project: Research
Research output
- 42 Article
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CD24 is required for sustained transparency of the adult lens
Shihan, M. H., Balasubramanian, R., Wang, Y., Rafi, R., Faranda, A. P., Parreno, J., Varadaraj, K., Gao, J., Mathias, R. T., Nie, X. & Duncan, M. K., Jun 2025, In: Experimental Eye Research. 255, 110347.Research output: Contribution to journal › Article › peer-review
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Functional characterization of CatTohm, a mouse AQP0 mutation that causes oxidative stress, cytotoxicity, dominant congenital lens cataract and microphthalmia
Kumari, S., Okamura, T. & Varadaraj, K., Aug 2025, In: Experimental Eye Research. 257, 110434.Research output: Contribution to journal › Article › peer-review
1 Scopus citations -
Studies on Hydrostatic Pressure Responses to Piezo1 and TRPV4 in the Mouse Lens
Gao, J., Mathias, R. T., Varadaraj, K., Shahidullah, M., Mei, J. & Delamere, N. A., Oct 2025, In: Investigative Ophthalmology and Visual Science. 66, 13, 20.Research output: Contribution to journal › Article › peer-review
Open Access -
Effect of hydrogen peroxide on lens transparency, intracellular pH, gap junction coupling, hydrostatic pressure and membrane water permeability
Varadaraj, K., Gao, J., Mathias, R. T. & Kumari, S., Aug 2024, In: Experimental Eye Research. 245, 109957.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Assessing Corneal Endothelial Damage Using Terahertz Time-Domain Spectroscopy and Support Vector Machines
Chen, A., Harris, Z. B., Virk, A., Abazari, A., Varadaraj, K., Honkanen, R. & Arbab, M. H., Dec 2022, In: Sensors. 22, 23, 9071.Research output: Contribution to journal › Article › peer-review
Open Access30 Scopus citations