Grants & Projects per year
Personal profile
Research interests
RNA alternative splicing (AS) is a finely tuned process through which pre-messenger RNA (pre-mRNA) is processed into two or more mature RNA (mRNA) isoforms in the nucleus, contributing to proteome diversity and gene-expression regulation.Cancer cells often exhibit aberrant splicing profiles, leading to the production of isoforms that increase cell proliferation, migration, or resistance to apoptosis.
Our laboratory seeks to understand the mechanisms by which RNA splicing is dysregulated to promote tumorigenesis and progression. We utilize transgenic mouse models and organoid culture to investigate the regulation of RNA splicing in physiological conditions and its dysregulation in inflammation and pancreatic cancer. Our expertise in small molecules and antisense technology enables us to modulate aberrant splicing in order to develop promising drugs for cancer therapy.
Fingerprint
Dive into the research topics where Ledong Wan is active. These topic labels come from the works of this person. Together they form a unique fingerprint.
- 1 Similar Profiles
Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
Grants & Projects
- 1 Active
-
Institutional Research Grant 2022
Frohman, M. (PI), Andrzejczyk, A. (CoI), Damaghi, M. (CoI), Guillaume, A. (CoI), Houghton, J. (CoI), Lee, C. (CoI), Liu, S. (CoI), Luberto, C. (CoI), Malik, S. (CoI), Mani, K. (CoI), Prasanna, P. (CoI), Rahme, G. (CoI), Scarbrough, K. H. (CoI), Stopeck, A. (CoI), Velazquez, F. N. (CoI), Vorkas, C. K. (CoI), Wan, L. (CoI), Bandovic, J. (CoI), Li, E. (CoI), Orfanelli, T. (CoI), Qiu, Y. (CoI), Thakur, C. (CoI) & Rageul, J. (CoI)
01/1/22 → …
Project: Research
-
Splice-switching ASOs targeting the AURKA 5′ UTR collapse an SRSF1-AURKA-MYC oncogenic circuit in pancreatic cancer
Kral, A. J., Jia, L., Sim, G. Y., Wan, L., Ishigami, Y. & Krainer, A. R., Jan 8 2026, In: Molecular Cell. 86, 1, p. 60-77.e7Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Transcriptomic regulation of pancreatic acinar cell homeostasis and plasticity
Zhang, X., Luo, C., Coughlin, K., Li, F. Q., Takemaru, K. I. & Wan, L., Jun 2026, In: Biochemical Society transactions. 54, 6, p. 681-697 17 p.Research output: Contribution to journal › Review article › peer-review
Open Access -
Splicing factor RBM10 loss fuels thyroid cancer metastasis
Coughlin, K. & Wan, L., May 5 2025, In: Journal of Experimental Medicine. 222, 5Research output: Contribution to journal › Article › peer-review
Open Access -
Chronic stress increases metastasis via neutrophil-mediated changes to the microenvironment
He, X. Y., Gao, Y., Ng, D., Michalopoulou, E., George, S., Adrover, J. M., Sun, L., Albrengues, J., Daßler-Plenker, J., Han, X., Wan, L., Wu, X. S., Shui, L. S., Huang, Y. H., Liu, B., Su, C., Spector, D. L., Vakoc, C. R., Van Aelst, L. & Egeblad, M., Mar 11 2024, In: Cancer Cell. 42, 3, p. 474-486.e12Research output: Contribution to journal › Article › peer-review
Open Access225 Scopus citations -
Interaction between MED12 and ΔNp63 activates basal identity in pancreatic ductal adenocarcinoma
Maia-Silva, D., Cunniff, P. J., Schier, A. C., Skopelitis, D., Trousdell, M. C., Moresco, P., Gao, Y., Kechejian, V., He, X. Y., Sahin, Y., Wan, L., Alpsoy, A., Liverpool, J., Krainer, A. R., Egeblad, M., Spector, D. L., Fearon, D. T., dos Santos, C. O., Taatjes, D. J. & Vakoc, C. R., Jul 2024, In: Nature Genetics. 56, 7, p. 1377-1385 9 p.Research output: Contribution to journal › Letter › peer-review
Open Access11 Scopus citations