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Research interests
My laboratory studies the neural mechanisms underlying auditory-guided behaviors. Dorsal striatum is a key brain region in sensory-guided behaviors including decision-making and learning. We initiated a series of investigations to determine how neural circuits connecting the auditory striatum, a posterior sub-region of the dorsal striatum, regulate auditory-guided behaviors including: 1) transformation from auditory cues to motor action; 2) modulation of attention and vigilance states on auditory processing; and 3) learning induced changes in the circuitry that enable the association between auditory cues and motor actions. We use interdisciplinary and state-of-the-art approaches including rodent behavioral paradigms, in vivo and in vitro electrophysiological recordings, in vivo calcium imaging, and chemogenetic and optogenetic techniques to arrive at information about structure/function relationships that support auditory-cued behaviors at their highest levels.
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Collaborations and top research areas from the last five years
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Activity-dependent astrocyte glucose dynamics regulate hippocampal neurogenesis
Ge, S. (PI) & Xiong, Q. (CoPI)
01/1/25 → 12/31/26
Project: Research
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CRCNS: TopoVess: A Topology-Infomred Vasculature Analysis Platform for Neuroscience
Chen, C. (PI) & Xiong, Q. (CoPI)
National Inst of Neurological Disorders & Stroke
12/5/24 → 11/30/26
Project: Research
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Center for Healthy Aging Pilot Program
Igarashi, P. (PI), DeLorenzo, C. (CoPI), Fields, S. (CoPI), Acosta, M. (CoI), Colognato, H. (CoI), Enikolopov, G. (CoI), Heslin, S. M. (CoI), Hu, C.-K. (CoI), Kaczocha, M. (CoI), Kim, H. (CoI), Kim, M. J. (CoI), Kumar, P. (CoI), Mackow, E. (CoI), Mathew, J. (CoI), Nadkarni, N. (CoI), Parker, M. (CoI), Rajupet, S. (CoI), Reich Marshall, N. C. (CoI), Riessland, M. (CoI), Rozensky, R. E. (CoI), Sher, R. (CoI), Sheridan, B. (CoI), Singer, A. (CoI), Sunar, U. (CoI), Tsirka, S. E. (CoI), Vorkas, C. K. (CoI), Wang, J. (CoI), Xiong, Q. (CoI) & Ye, F. (CoI)
08/1/23 → 12/31/27
Project: Research
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Thomas Hartman Center for Parkinson's Research
Fontanini, A. (PI), Bowen, M. E. (CoI), Collins III, W. (CoI), Colognato, H. (CoI), Hu, C.-K. (CoI), Kritzer, M. (CoI), Lamberg, E. M. (CoI), Leung, H. C. (CoI), Maffei, A. (CoI), Maurer, C. (CoI), Muratori, L. M. (CoI), Neiman, A. (CoI), Plotkin, J. (CoI), Puopolo, M. (CoI), Riessland, M. (CoI), Schwartz, G. (CoI), Shelly, M. (CoI), Sher, R. (CoI), Shrestha, P. (CoI), Sirotkin, H. I. (CoI), Solomon, I. C. (CoI), Thomsen IV, G. H. (CoI), Wollmuth, L. (CoI), Wu, S. (CoI), Xiong, Q. (CoI), Role, L. (PI), Christodoulou, C. (CoI), Evinger, L. (CoI), Halegoua, S. (CoI), Huang, C. (CoI), Levine, J. (CoI), Lutterbie, J. (CoI), Manganas, L. (CoI), Matthews, G. (CoI), Park, I. M. (CoI) & Talmage, D. (CoI)
04/15/13 → 07/31/27
Project: Research
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The Role of Striatal Neurovascular Coupling in Learning
Xiong, Q. (PI) & Wu, S. (CoPI)
National Inst of Neurological Disorders & Stroke
06/1/23 → 05/31/25
Project: Research
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Astrocytic glucose metabolism regulates the survival of newborn hippocampal neurons in the adult brain
Wang, X., Chen, L., Kim, T. A., Wang, Z., Peng, X., Syty, M. D., Wang, F., Zhang, Y., Wehrle, P., Nasu, Y., Xiong, Q. & Ge, S., 2026, (Accepted/In press) In: Neuron.Research output: Contribution to journal › Article › peer-review
Open Access -
Neural circuit mechanisms underlying aberrantly prolonged functional hyperemia in young Alzheimer’s disease mice
Kim, T. A., Cruz, G., Syty, M. D., Wang, F., Wang, X., Duan, A., Halterman, M., Xiong, Q., Palop, J. J. & Ge, S., Feb 2025, In: Molecular Psychiatry. 30, 2, p. 367-378 12 p., 11934.Stony Brook University, University at Buffalo
Research output: Contribution to journal › Article › peer-review
Open Access6 Scopus citations -
The zona incerta negatively regulates the red nucleus during movement cued by sound signals
Chen, L., Wang, X., Liu, H., He, C., Chen, A. P. F., Chen, L., Kim, T. A. & Xiong, Q., Apr 2025, In: PLOS Biology. 23, 4, e3003092.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Topological Analysis of Mouse Brain Vasculature via 3d Light-Sheet Microscopy Images
Yao, J., Hagemann, N., Xiong, Q., Chen, J., Hermann, D. M. & Chen, C., 2024, IEEE International Symposium on Biomedical Imaging, ISBI 2024 - Conference Proceedings. IEEE Computer Society, (Proceedings - International Symposium on Biomedical Imaging).Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review
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Nigrostriatal dopamine modulates the striatal-amygdala pathway in auditory fear conditioning
Chen, A. P. F., Chen, L., Shi, K. W., Cheng, E., Ge, S. & Xiong, Q., Dec 2023, In: Nature Communications. 14, 1, 7231.Research output: Contribution to journal › Article › peer-review
Open Access22 Scopus citations