Personal profile
Research interests
My expertise lies in molecular genetic analyses of developmental processes in model systems. My lab investigates the roles of conserved transcription regulators in the development of sensory systems, including the eye. We aim to identify proteins, signals and genome features that serve as determinants of transcription regulator function and specificity during critical periods of development, such as during neural versus non-neural fate specification in the primordial eye tissue, and later in development, during eye morphogenesis. My recent investigations have focused on the genetic networks that regulate the Hippo-Yki and Mitf signaling axes in the developing eye, and I am currently funded to investigate the links between these signaling cascades and the expression of ocular extracellular matrix.
Education/Academic qualification
PhD, Molecular and Cell Biology, Brandeis University
Aug 2008 → Apr 2015
Master, Zoology, University of Toronto
Sep 2001 → Nov 2005
Bachelor, Biology and Forensic Science, University of Toronto
Sep 1996 → May 2000
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Collaborations and top research areas from the last five years
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The third intracellular loop of Drosophila Lilipod is required for protein function in vivo and can mediate protein-protein interactions in vitro
Roy, M. V., Neal, S. J. & Pignoni, F., Jun 2025, In: PLoS ONE. 20, 6 June, e0325326.Research output: Contribution to journal › Article › peer-review
Open Access -
Mitf, with Yki and STRIPAK-PP2A, is a key determinant of form and fate in the progenitor epithelium of the Drosophila eye.
Zhang, T., Zhou, Q., Jusić, N., Lu, W., Pignoni, F. & Neal, S. J., Jun 2024, In: European Journal of Cell Biology. 103, 2, 151421.Research output: Contribution to journal › Article › peer-review
Open Access8 Scopus citations -
Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes
Neal, S. J., Rajasekaran, A., Jusić, N., Taylor, L., Read, M., Alfandari, D., Pignoni, F. & Moody, S. A., May 2024, In: Journal of Experimental Zoology Part B: Molecular and Developmental Evolution. 342, 3, p. 212-240 29 p.Research output: Contribution to journal › Review article › peer-review
Open Access5 Scopus citations -
Peripodial adherens junctions regulate Ajuba-Yorkie signaling to preserve fly eye morphology
DeSantis, D. F., Neal, S. J., Zhou, Q. & Pignoni, F., Mar 2023, In: Biology Open. 12, 3, bio059579.Research output: Contribution to journal › Article › peer-review
Open Access2 Scopus citations -
Protein Phosphatase 2A with B′ specificity subunits regulates the Hippo-Yorkie signaling axis in the Drosophila eye disc
Neal, S. J., Zhou, Q. & Pignoni, F., Oct 2022, In: Journal of Cell Science. 135, 20, jcs259558.Research output: Contribution to journal › Article › peer-review
Open Access5 Scopus citations