Grants & Projects per year
Personal profile
Research interests
The Yang lab focuses on harnessing the power of multi-level proteomics technologies, such as global proteomics, phosphoproteomics, palmitoyl-proteomics, interactome profiling, thermal proteome profiling, and targeted proteomics, to delineate the molecular mechanisms of cancer metastasis. The ultimate goal is to identify promising drug targets and reliable biomarkers, enabling precision treatment of patients facing a high risk of metastatic progression.
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Collaborations and top research areas from the last five years
Recent external collaboration on country/territory level. Dive into details by clicking on the dots or
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Investigating Targetable Mechanisms of Altered Cell States in Castration-Resistant Prostrate Cancer
Talos, F. M. (PI), Nemajerova, A. (CoPI), Yang, W. (CoPI) & Yurovsky, A. (CoPI)
07/1/26 → 06/30/27
Project: Research
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Transfer: RIPK2 as a Therapeutic Target in Advanced Prostate Cancers
Yang, W. (PI)
US Army Medical Research Acquisition Activity
08/31/24 → 12/31/26
Project: Research
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Transfer: RIPK2/MKK7/c-Myc Signaling as a Therapeutic Target in Prostate Cancer Metastasis
Yang, W. (PI)
06/1/24 → 05/31/27
Project: Research
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Molecular Profiling of the Tumor Microenvironment in Prostate Cancer Progression
Yang, W. (PI)
08/1/25 → 07/31/26
Project: Research
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A RIPK2 activity signature in prostate cancer: Modulation by RIPK2 inhibition and clinical association
Elgehama, A. M., Yang, Q., Pires Sanches, J. G., He, Z., Ruegg, L., You, S. & Yang, W., Jul 2026, In: Translational Oncology. 69, 102819.Research output: Contribution to journal › Article › peer-review
Open Access -
Extracellular vesicle heterogeneity through the lens of multiomics
Silva, T. F., Hutchins, E., Zhao, W., Ciani, Y., Kim, M., Ko, E., Mariscal, J., Qiu, Z., Bedier, F., Kittel, A., Zhou, B., Wang, Y., Hall, M., Galasso, F., Reiman, R., Freeman, M. R., Parker, S., Van Eyk, J., Yang, W. & Posadas, E. & 10 others, , Jul 15 2025, In: Cell Reports Medicine. 6, 7, 102161.Research output: Contribution to journal › Article › peer-review
Open Access41 Scopus citations -
Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury
Gheinani, A. H., Sack, B. S., Bigger-Allen, A., Thaker, H., Atta, H., Lambrinos, G., Costa, K., Doyle, C., Gharaee-Kermani, M., Patalano, S., Piper, M., Cotellessa, J. F., Vitko, D., Li, H., Prabhakaran, M. K., Cristofaro, V., Froehlich, J., Lee, R. S., Yang, W. & Sullivan, M. P. & 2 others, , Jun 2025, In: JCI Insight. 10, 12, e180275.Research output: Contribution to journal › Article › peer-review
Open Access7 Scopus citations -
ONECUT2 acts as a lineage plasticity driver in adenocarcinoma as well as neuroendocrine variants of prostate cancer
Qian, C., Yang, Q., Rotinen, M., Huang, R., Kim, H., Gallent, B., Yan, Y., Cadaneanu, R. M., Zhang, B., Kaochar, S., Freedland, S. J., Posadas, E. M., Ellis, L., Vizio, D. D., Morrissey, C., Nelson, P. S., Brady, L., Murali, R., Campbell, M. J. & Yang, W. & 6 others, , Jul 22 2024, In: Nucleic Acids Research. 52, 13, p. 7740-7760 21 p.Research output: Contribution to journal › Article › peer-review
Open Access39 Scopus citations -
Profiling phagosome proteins identifies PD-L1 as a fungal-binding receptor
Li, K., Chatterjee, A., Qian, C., Lagree, K., Wang, Y., Becker, C. A., Freeman, M. R., Murali, R., Yang, W. & Underhill, D. M., Jun 20 2024, In: Nature. 630, 8017, p. 736-743 8 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Scopus citations