Project Details
Description
The goals of this project are to study the immunomodulatory activities of
LT-IIa and LT-IIb. Both toxins are potent mucosal adjuvants which elicit
patterns of immune responses distinct from those elicited by cholera toxin. The
toxins will be used as molecular tools to investigate the mechanisms that
regulate adjuvant activity. We will engineer a new class of recombinant toxins
to evaluate as potential mucosal vaccines.
| Status | Finished |
|---|---|
| Effective start/end date | 05/1/02 → 01/31/07 |
Funding
- National Institute of Dental & Craniofacial Res: $526,014.00
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