70K heat shock related proteins stimulate protein translocation into microsomes

William J. Chirico; M. Gerard Waters; Günter Blobel

doi:10.1038/332805a0

70K heat shock related proteins stimulate protein translocation into microsomes

William J. Chirico
, M. Gerard Waters
, Günter Blobel

Cell / Cellular Biology and Anatomical Sciences

SUNY Downstate Health Sciences University

Rockefeller University

Research output: Contribution to journal › Article › peer-review

1002 Scopus citations

Abstract

A yeast cytosol is shown to contain two distinct activities that stimulate protein translocation across microsomal membranes. One activity was purified. It consists of two constitutively expressed 70K heat shock related proteins that increase the rate of translocation. Possible mechanisms of action of these proteins are discussed.

Original language	English
Pages (from-to)	805-810
Number of pages	6
Journal	Nature
Volume	332
Issue number	6167
DOIs	https://doi.org/10.1038/332805a0
State	Published - 1988

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@article{5518d915db214fe79ee843f168af66e9,

title = "70K heat shock related proteins stimulate protein translocation into microsomes",

abstract = "A yeast cytosol is shown to contain two distinct activities that stimulate protein translocation across microsomal membranes. One activity was purified. It consists of two constitutively expressed 70K heat shock related proteins that increase the rate of translocation. Possible mechanisms of action of these proteins are discussed.",

author = "Chirico, \{William J.\} and Waters, \{M. Gerard\} and G{\"u}nter Blobel",

year = "1988",

doi = "10.1038/332805a0",

language = "English",

volume = "332",

pages = "805--810",

journal = "Nature",

issn = "0028-0836",

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TY - JOUR

T1 - 70K heat shock related proteins stimulate protein translocation into microsomes

AU - Chirico, William J.

AU - Waters, M. Gerard

AU - Blobel, Günter

PY - 1988

Y1 - 1988

N2 - A yeast cytosol is shown to contain two distinct activities that stimulate protein translocation across microsomal membranes. One activity was purified. It consists of two constitutively expressed 70K heat shock related proteins that increase the rate of translocation. Possible mechanisms of action of these proteins are discussed.

AB - A yeast cytosol is shown to contain two distinct activities that stimulate protein translocation across microsomal membranes. One activity was purified. It consists of two constitutively expressed 70K heat shock related proteins that increase the rate of translocation. Possible mechanisms of action of these proteins are discussed.

UR - https://www.scopus.com/pages/publications/0024298706

U2 - 10.1038/332805a0

DO - 10.1038/332805a0

M3 - Article

C2 - 3282179

SN - 0028-0836

VL - 332

SP - 805

EP - 810

JO - Nature

JF - Nature

IS - 6167

ER -

70K heat shock related proteins stimulate protein translocation into microsomes

Abstract

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