TY - GEN
T1 - A cascaded refinement GAN for phase contrast microscopy image super resolution
AU - Han, Liang
AU - Yin, Zhaozheng
N1 - Publisher Copyright: © Springer Nature Switzerland AG 2018.
PY - 2018
Y1 - 2018
N2 - Phase contrast microscopy is a widely-used non-invasive technique for monitoring live cells over time. High-throughput biological experiments expect a wide-view (i.e., a low microscope magnification) to monitor the entire cell population and a high magnification on individual cell’s details, which is hard to achieve simultaneously. In this paper, we propose a cascaded refinement Generative Adversarial Network (GAN) for phase contrast microscopy image super-resolution. Our algorithm uses an optic-related data enhancement and super-resolves a phase contrast microscopy image in a coarse-to-fine fashion, with a new loss function consisting of a content loss and an adversarial loss. The proposed algorithm is both qualitatively and quantitatively evaluated on a dataset of 500 phase contrast microscopy images, showing its superior performance for super-resolving phase contrast microscopy images. The proposed algorithm provides a computational solution on achieving a high magnification on individual cell’s details and a wide-view on cell populations at the same time, which will benefit the microscopy community.
AB - Phase contrast microscopy is a widely-used non-invasive technique for monitoring live cells over time. High-throughput biological experiments expect a wide-view (i.e., a low microscope magnification) to monitor the entire cell population and a high magnification on individual cell’s details, which is hard to achieve simultaneously. In this paper, we propose a cascaded refinement Generative Adversarial Network (GAN) for phase contrast microscopy image super-resolution. Our algorithm uses an optic-related data enhancement and super-resolves a phase contrast microscopy image in a coarse-to-fine fashion, with a new loss function consisting of a content loss and an adversarial loss. The proposed algorithm is both qualitatively and quantitatively evaluated on a dataset of 500 phase contrast microscopy images, showing its superior performance for super-resolving phase contrast microscopy images. The proposed algorithm provides a computational solution on achieving a high magnification on individual cell’s details and a wide-view on cell populations at the same time, which will benefit the microscopy community.
UR - https://www.scopus.com/pages/publications/85054087273
U2 - 10.1007/978-3-030-00934-2_39
DO - 10.1007/978-3-030-00934-2_39
M3 - Conference contribution
SN - 9783030009335
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 347
EP - 355
BT - Medical Image Computing and Computer Assisted Intervention – MICCAI 2018 - 21st International Conference, 2018, Proceedings
A2 - Fichtinger, Gabor
A2 - Davatzikos, Christos
A2 - Alberola-López, Carlos
A2 - Frangi, Alejandro F.
A2 - Schnabel, Julia A.
PB - Springer Verlag
T2 - 21st International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2018
Y2 - 16 September 2018 through 20 September 2018
ER -