TY - JOUR
T1 - A cross-sectional study of functional and metabolic changes during aging through the lifespan in male mice
AU - Petr, Michael A.
AU - Alfaras, Irene
AU - Krawcyzk, Melissa
AU - Bair, Woei Nan
AU - Mitchell, Sarah J.
AU - Morrell, Christopher H.
AU - Studenski, Stephanie A.
AU - Price, Nathan L.
AU - Fishbein, Kenneth W.
AU - Spencer, Richard G.
AU - Scheibye-Knudsen, Morten
AU - Lakatta, Edward G.
AU - Ferrucci, Luigi
AU - Aon, Miguel A.
AU - Bernier, Michel
AU - de Cabo, Rafael
N1 - Publisher Copyright: © 2021, eLife Sciences Publications Ltd. All rights reserved.
PY - 2021
Y1 - 2021
N2 - Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.
AB - Aging is associated with distinct phenotypical, physiological, and functional changes, leading to disease and death. The progression of aging-related traits varies widely among individuals, influenced by their environment, lifestyle, and genetics. In this study, we conducted physiologic and functional tests cross-sectionally throughout the entire lifespan of male C57BL/6N mice. In parallel, metabolomics analyses in serum, brain, liver, heart, and skeletal muscle were also performed to identify signatures associated with frailty and age-dependent functional decline. Our findings indicate that declines in gait speed as a function of age and frailty are associated with a dramatic increase in the energetic cost of physical activity and decreases in working capacity. Aging and functional decline prompt organs to rewire their metabolism and substrate selection and toward redox-related pathways, mainly in liver and heart. Collectively, the data provide a framework to further understand and characterize processes of aging at the individual organism and organ levels.
UR - https://www.scopus.com/pages/publications/85105298420
U2 - 10.7554/ELIFE.62952
DO - 10.7554/ELIFE.62952
M3 - Article
C2 - 33876723
SN - 2050-084X
VL - 10
JO - eLife
JF - eLife
M1 - e62952
ER -