A Fever-Th17 Cell Immune Axis: Some SMADs Like It Hot

Sharon S. Evans; Michelle M. Appenheimer

doi:10.1016/j.immuni.2020.01.010

A Fever-Th17 Cell Immune Axis: Some SMADs Like It Hot

Sharon S. Evans
, Michelle M. Appenheimer

Roswell Park - Tumor Immunology

University at Buffalo

Roswell Park Cancer Institute

Research output: Contribution to journal › Comment/debate

6 Scopus citations

Abstract

Fever has beneficial effects on immune responses; however, its impact on T cell polarization is poorly understood. In this issue of Immunity, Wang et al. show that fever acts through a T cell-intrinsic SMAD4-dependent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.

Original language	English
Pages (from-to)	209-211
Number of pages	3
Journal	Immunity
Volume	52
Issue number	2
DOIs	https://doi.org/10.1016/j.immuni.2020.01.010
State	Published - Feb 18 2020

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title = "A Fever-Th17 Cell Immune Axis: Some SMADs Like It Hot",

abstract = "Fever has beneficial effects on immune responses; however, its impact on T cell polarization is poorly understood. In this issue of Immunity, Wang et al. show that fever acts through a T cell-intrinsic SMAD4-dependent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.",

author = "Evans, \{Sharon S.\} and Appenheimer, \{Michelle M.\}",

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T1 - A Fever-Th17 Cell Immune Axis

T2 - Some SMADs Like It Hot

AU - Evans, Sharon S.

AU - Appenheimer, Michelle M.

PY - 2020/2/18

Y1 - 2020/2/18

N2 - Fever has beneficial effects on immune responses; however, its impact on T cell polarization is poorly understood. In this issue of Immunity, Wang et al. show that fever acts through a T cell-intrinsic SMAD4-dependent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.

AB - Fever has beneficial effects on immune responses; however, its impact on T cell polarization is poorly understood. In this issue of Immunity, Wang et al. show that fever acts through a T cell-intrinsic SMAD4-dependent mechanism that selectively drives Th17 cell differentiation and pathogenicity in autoimmunity.

UR - https://www.scopus.com/pages/publications/85079146028

U2 - 10.1016/j.immuni.2020.01.010

DO - 10.1016/j.immuni.2020.01.010

M3 - Comment/debate

C2 - 32075722

SN - 1074-7613

VL - 52

SP - 209

EP - 211

JO - Immunity

JF - Immunity

IS - 2

ER -

A Fever-Th17 Cell Immune Axis: Some SMADs Like It Hot

Abstract

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