Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Chun Pin Chang; Shen Chih Chang; Shu Chun Chuang; Julien Berthiller; Gilles Ferro; Keitaro Matsuo; Victor Wünsch-Filho; Tatiana N. Toporcov; Marcos Brasilino de Carvalho; Carlo La Vecchia; Andrew F. Olshan; Jose P. Zevallos; Diego Serraino; Joshua Muscat; Erich M. Sturgis; Guojun Li; Hal Morgenstern; Fabio Levi; Luigino Dal Maso; Elaine Smith; Karl Kelsey; Michael McClean; Thomas L. Vaughan; Philip Lazarus; Heribert Ramroth; Chu Chen; Stephen M. Schwartz; Deborah M. Winn; Cristina Bosetti; Valeria Edefonti; Werner Garavello; Eva Negri; Richard B. Hayes; Mark P. Purdue; Stefania Boccia; Gabriella Cadoni; Oxana Shangina; Rosalina Koifman; Maria Paula Curado; Marta Vilensky; Beata Swiatkowska; Rolando Herrero; Silvia Franceschi; Simone Benhamou; Leticia Fernandez; Ana M.B. Menezes; Alexander W. Daudt; Dana Mates; Stimson Schantz; Guo Pei Yu; Jolanta Lissowska; Hermann Brenner; Eleonora Fabianova; Peter Rudnai; Paul Brennan; Paolo Boffetta; Zuo Feng Zhang; Mia Hashibe; Yuan Chin Amy Lee

doi:10.1016/j.canep.2019.101615

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

Chun Pin Chang
, Shen Chih Chang
, Shu Chun Chuang
, Julien Berthiller
, Gilles Ferro
, Keitaro Matsuo
, Victor Wünsch-Filho
, Tatiana N. Toporcov
, Marcos Brasilino de Carvalho
, Carlo La Vecchia
, Andrew F. Olshan
, Jose P. Zevallos
, Diego Serraino
, Joshua Muscat
, Erich M. Sturgis
, Guojun Li
, Hal Morgenstern
, Fabio Levi
, Luigino Dal Maso
, Elaine Smith

Karl Kelsey, Michael McClean, Thomas L. Vaughan, Philip Lazarus, Heribert Ramroth, Chu Chen, Stephen M. Schwartz, Deborah M. Winn, Cristina Bosetti, Valeria Edefonti, Werner Garavello, Eva Negri, Richard B. Hayes, Mark P. Purdue, Stefania Boccia, Gabriella Cadoni, Oxana Shangina, Rosalina Koifman, Maria Paula Curado, Marta Vilensky, Beata Swiatkowska, Rolando Herrero, Silvia Franceschi, Simone Benhamou, Leticia Fernandez, Ana M.B. Menezes, Alexander W. Daudt, Dana Mates, Stimson Schantz, Guo Pei Yu, Jolanta Lissowska, Hermann Brenner, Eleonora Fabianova, Peter Rudnai, Paul Brennan, Paolo Boffetta, Zuo Feng Zhang, Mia Hashibe, Yuan Chin Amy Lee

University at Buffalo, Stony Brook University

University of Utah
International Agency for Research on Cancer
University of California at Los Angeles
National Health Research Institutes Taiwan
Hospices civils de Lyon
Aichi Cancer Center Hospital and Research Institute
Nagoya University
Universidade de São Paulo
Hospital Heliópolis
University of Milan
University of North Carolina at Chapel Hill
Washington University St. Louis
Centro di Riferimento Oncologico di Aviano (CRO) IRCCS
Pennsylvania State University
University of Texas MD Anderson Cancer Center
University of Michigan, Ann Arbor
University of Lausanne
University of Iowa
Brown University
Fred Hutchinson Cancer Research Center
Heidelberg University
National Institutes of Health
IRCCS Istituto di ricerche farmacologiche Mario Negri - Milano, Bergamo, Ranica
University of Milan - Bicocca
New York University
Catholic University of the Sacred Heart
Fondazione Policlinico Universitario A. Gemelli IRCCS
Russian N.N. Blokhin Cancer Research Centre
Fundação Oswaldo Cruz
A.C.Camargo Cancer Center
Universidad de Buenos Aires
Nofer Institute of Occupational Medicine
Institut national de la santé et de la recherche médicale
National School of Public Health
Universidade Federal de Pelotas
Universidade Federal do Rio Grande do Sul
Institute of Public Health
Continuum Health Partners, Inc.
New York Medical College
Maria Sklodowska-Curie Institute of Oncology
German Cancer Research Center
Regional Authority of Public Health in BanskaBystrica
Hungarian National Institute of Environmental Health
Icahn School of Medicine at Mount Sinai
Universidade de São Paulo
University of Michigan, Ann Arbor
University of Iowa
Washington State University Spokane
New York University
Blokhin Cancer Research Center
AC Camargo Cancer Center
National Institute of Public Health

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR_{<10 years vs. ≥30 years}: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR_{<10 years vs. ≥30 years}: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

Original language	English
Article number	101615
Journal	Cancer Epidemiology
Volume	63
DOIs	https://doi.org/10.1016/j.canep.2019.101615
State	Published - Dec 2019

Keywords

Age at start of tobacco use
Head and neck cancer
Hypopharyngeal cancer
Laryngeal cancer
Oral cancer
Oropharyngeal cancer

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10.1016/j.canep.2019.101615

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Chang, C. P., Chang, S. C., Chuang, S. C., Berthiller, J., Ferro, G., Matsuo, K., Wünsch-Filho, V., Toporcov, T. N., de Carvalho, M. B., La Vecchia, C., Olshan, A. F., Zevallos, J. P., Serraino, D., Muscat, J., Sturgis, E. M., Li, G., Morgenstern, H., Levi, F., Dal Maso, L., ... Lee, Y. C. A. (2019). Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE). Cancer Epidemiology, 63, Article 101615. https://doi.org/10.1016/j.canep.2019.101615

@article{3fe3be95404e46d587d722ffcfa6aa19,

title = "Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)",

abstract = "Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95\% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95\% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95\% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.",

keywords = "Age at start of tobacco use, Head and neck cancer, Hypopharyngeal cancer, Laryngeal cancer, Oral cancer, Oropharyngeal cancer",

author = "Chang, \{Chun Pin\} and Chang, \{Shen Chih\} and Chuang, \{Shu Chun\} and Julien Berthiller and Gilles Ferro and Keitaro Matsuo and Victor W{\"u}nsch-Filho and Toporcov, \{Tatiana N.\} and \{de Carvalho\}, \{Marcos Brasilino\} and \{La Vecchia\}, Carlo and Olshan, \{Andrew F.\} and Zevallos, \{Jose P.\} and Diego Serraino and Joshua Muscat and Sturgis, \{Erich M.\} and Guojun Li and Hal Morgenstern and Fabio Levi and \{Dal Maso\}, Luigino and Elaine Smith and Karl Kelsey and Michael McClean and Vaughan, \{Thomas L.\} and Philip Lazarus and Heribert Ramroth and Chu Chen and Schwartz, \{Stephen M.\} and Winn, \{Deborah M.\} and Cristina Bosetti and Valeria Edefonti and Werner Garavello and Eva Negri and Hayes, \{Richard B.\} and Purdue, \{Mark P.\} and Stefania Boccia and Gabriella Cadoni and Oxana Shangina and Rosalina Koifman and Curado, \{Maria Paula\} and Marta Vilensky and Beata Swiatkowska and Rolando Herrero and Silvia Franceschi and Simone Benhamou and Leticia Fernandez and Menezes, \{Ana M.B.\} and Daudt, \{Alexander W.\} and Dana Mates and Stimson Schantz and Yu, \{Guo Pei\} and Jolanta Lissowska and Hermann Brenner and Eleonora Fabianova and Peter Rudnai and Paul Brennan and Paolo Boffetta and Zhang, \{Zuo Feng\} and Mia Hashibe and Lee, \{Yuan Chin Amy\}",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

doi = "10.1016/j.canep.2019.101615",

language = "English",

volume = "63",

journal = "Cancer Epidemiology",

issn = "1877-7821",

publisher = "Elsevier Ltd.",

}

Chang, CP, Chang, SC, Chuang, SC, Berthiller, J, Ferro, G, Matsuo, K, Wünsch-Filho, V, Toporcov, TN, de Carvalho, MB, La Vecchia, C, Olshan, AF, Zevallos, JP, Serraino, D, Muscat, J, Sturgis, EM, Li, G, Morgenstern, H, Levi, F, Dal Maso, L, Smith, E, Kelsey, K, McClean, M, Vaughan, TL, Lazarus, P, Ramroth, H, Chen, C, Schwartz, SM, Winn, DM, Bosetti, C, Edefonti, V, Garavello, W, Negri, E, Hayes, RB, Purdue, MP, Boccia, S, Cadoni, G, Shangina, O, Koifman, R, Curado, MP, Vilensky, M, Swiatkowska, B, Herrero, R, Franceschi, S, Benhamou, S, Fernandez, L, Menezes, AMB, Daudt, AW, Mates, D, Schantz, S, Yu, GP, Lissowska, J, Brenner, H, Fabianova, E, Rudnai, P, Brennan, P, Boffetta, P, Zhang, ZF, Hashibe, M & Lee, YCA 2019, 'Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)', Cancer Epidemiology, vol. 63, 101615. https://doi.org/10.1016/j.canep.2019.101615

TY - JOUR

T1 - Age at start of using tobacco on the risk of head and neck cancer

T2 - Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

AU - Chang, Chun Pin

AU - Chang, Shen Chih

AU - Chuang, Shu Chun

AU - Berthiller, Julien

AU - Ferro, Gilles

AU - Matsuo, Keitaro

AU - Wünsch-Filho, Victor

AU - Toporcov, Tatiana N.

AU - de Carvalho, Marcos Brasilino

AU - La Vecchia, Carlo

AU - Olshan, Andrew F.

AU - Zevallos, Jose P.

AU - Serraino, Diego

AU - Muscat, Joshua

AU - Sturgis, Erich M.

AU - Li, Guojun

AU - Morgenstern, Hal

AU - Levi, Fabio

AU - Dal Maso, Luigino

AU - Smith, Elaine

AU - Kelsey, Karl

AU - McClean, Michael

AU - Vaughan, Thomas L.

AU - Lazarus, Philip

AU - Ramroth, Heribert

AU - Chen, Chu

AU - Schwartz, Stephen M.

AU - Winn, Deborah M.

AU - Bosetti, Cristina

AU - Edefonti, Valeria

AU - Garavello, Werner

AU - Negri, Eva

AU - Hayes, Richard B.

AU - Purdue, Mark P.

AU - Boccia, Stefania

AU - Cadoni, Gabriella

AU - Shangina, Oxana

AU - Koifman, Rosalina

AU - Curado, Maria Paula

AU - Vilensky, Marta

AU - Swiatkowska, Beata

AU - Herrero, Rolando

AU - Franceschi, Silvia

AU - Benhamou, Simone

AU - Fernandez, Leticia

AU - Menezes, Ana M.B.

AU - Daudt, Alexander W.

AU - Mates, Dana

AU - Schantz, Stimson

AU - Yu, Guo Pei

AU - Lissowska, Jolanta

AU - Brenner, Hermann

AU - Fabianova, Eleonora

AU - Rudnai, Peter

AU - Brennan, Paul

AU - Boffetta, Paolo

AU - Zhang, Zuo Feng

AU - Hashibe, Mia

AU - Lee, Yuan Chin Amy

PY - 2019/12

Y1 - 2019/12

N2 - Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

AB - Background: Tobacco use is a well-established risk factor for head and neck cancer (HNC). However, less is known about the potential impact of exposure to tobacco at an early age on HNC risk. Methods: We analyzed individual-level data on ever tobacco smokers from 27 case-control studies (17,146 HNC cases and 17,449 controls) in the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Adjusted odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using random-effects logistic regression models. Results: Without adjusting for tobacco packyears, we observed that younger age at starting tobacco use was associated with an increased HNC risk for ever smokers (OR<10 years vs. ≥30 years: 1.64, 95% CI: 1.35, 1.97). However, the observed association between age at starting tobacco use and HNC risk became null after adjusting for tobacco packyears (OR<10 years vs. ≥30 years: 0.97, 95% CI: 0.80, 1.19). In the stratified analyses on HNC subsites by tobacco packyears or years since quitting, no difference in the association between age at start and HNC risk was observed. Conclusions: Results from this pooled analysis suggest that increased HNC risks observed with earlier age at starting tobacco smoking are largely due to longer duration and higher cumulative tobacco exposures.

KW - Age at start of tobacco use

KW - Head and neck cancer

KW - Hypopharyngeal cancer

KW - Laryngeal cancer

KW - Oral cancer

KW - Oropharyngeal cancer

UR - https://www.scopus.com/pages/publications/85072785945

U2 - 10.1016/j.canep.2019.101615

DO - 10.1016/j.canep.2019.101615

M3 - Article

C2 - 31586822

SN - 1877-7821

VL - 63

JO - Cancer Epidemiology

JF - Cancer Epidemiology

M1 - 101615

ER -

Age at start of using tobacco on the risk of head and neck cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium (INHANCE)

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Keywords

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