Abstract
Proteins of the plasma-bradykinin-forming cascade can be assembled along the surface of endothelial cells and the cell receptors identified include gC1qR and cytokeratin 1, which interact with high-molecular-weight kininogen (HK) and Factor XII. Antisera to gC1qR and cytokeratin 1 inhibit not only binding of ilK to the cell surface, but also prevent activation of normal plasma to produce bradykinin. Factor-XII-deficient or HK-deficient plasma, incubated with endothelial cells do not activate; therefore, the surface of cells may be a physiologic initiator of the plasma-bradykinin-forming cells and the process may be augmented when tissue injury occurs.
| Translated title of the contribution | Activation of the plasma-kinin-forming cascade along cell surfaces |
|---|---|
| Original language | German |
| Pages (from-to) | 407-410 |
| Number of pages | 4 |
| Journal | Allergo Journal |
| Volume | 9 |
| Issue number | 7 |
| DOIs | |
| State | Published - 2000 |
Keywords
- Bradykinin
- Endothelial cells
- Factor XII
- Kininogen
- Prakallikrein
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