All in the Family: Repeats and ALS/FTD

Amrutha Pattamatta; John D. Cleary; Laura P.W. Ranum

doi:10.1016/j.tins.2018.03.010

All in the Family: Repeats and ALS/FTD

Amrutha Pattamatta
, John D. Cleary
, Laura P.W. Ranum

Institute for RNA Science and Technology

University at Albany

University of Florida

Research output: Contribution to journal › Short survey › peer-review

7 Scopus citations

Abstract

In 2011, an intronic (G₄C₂)•(G₂C₄) expansion was shown to cause the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This discovery linked ALS with a clinically distinct form of dementia and a larger group of microsatellite repeat diseases, and catalyzed basic and translational research.

Original language	English
Pages (from-to)	247-250
Number of pages	4
Journal	Trends in Neurosciences
Volume	41
Issue number	5
DOIs	https://doi.org/10.1016/j.tins.2018.03.010
State	Published - May 2018

Keywords

ALS
C9orf72
CCGGGG
FTD
GGGGCC
RAN translation
RNA foci
amyotrophic lateral sclerosis
frontotemporal dementia
repeat-associated non-ATG translation

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10.1016/j.tins.2018.03.010

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@article{572910ceeb374b3c973d13556a3fc688,

title = "All in the Family: Repeats and ALS/FTD",

abstract = "In 2011, an intronic (G4C2)•(G2C4) expansion was shown to cause the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This discovery linked ALS with a clinically distinct form of dementia and a larger group of microsatellite repeat diseases, and catalyzed basic and translational research.",

keywords = "ALS, C9orf72, CCGGGG, FTD, GGGGCC, RAN translation, RNA foci, amyotrophic lateral sclerosis, frontotemporal dementia, repeat-associated non-ATG translation",

author = "Amrutha Pattamatta and Cleary, \{John D.\} and Ranum, \{Laura P.W.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",

year = "2018",

month = may,

doi = "10.1016/j.tins.2018.03.010",

language = "English",

volume = "41",

pages = "247--250",

journal = "Trends in Neurosciences",

issn = "0166-2236",

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TY - JOUR

T1 - All in the Family

T2 - Repeats and ALS/FTD

AU - Pattamatta, Amrutha

AU - Cleary, John D.

AU - Ranum, Laura P.W.

PY - 2018/5

Y1 - 2018/5

N2 - In 2011, an intronic (G4C2)•(G2C4) expansion was shown to cause the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This discovery linked ALS with a clinically distinct form of dementia and a larger group of microsatellite repeat diseases, and catalyzed basic and translational research.

AB - In 2011, an intronic (G4C2)•(G2C4) expansion was shown to cause the most common forms of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). This discovery linked ALS with a clinically distinct form of dementia and a larger group of microsatellite repeat diseases, and catalyzed basic and translational research.

KW - ALS

KW - C9orf72

KW - CCGGGG

KW - FTD

KW - GGGGCC

KW - RAN translation

KW - RNA foci

KW - amyotrophic lateral sclerosis

KW - frontotemporal dementia

KW - repeat-associated non-ATG translation

UR - https://www.scopus.com/pages/publications/85044591270

U2 - 10.1016/j.tins.2018.03.010

DO - 10.1016/j.tins.2018.03.010

M3 - Short survey

C2 - 29703376

SN - 0166-2236

VL - 41

SP - 247

EP - 250

JO - Trends in Neurosciences

JF - Trends in Neurosciences

IS - 5

ER -

All in the Family: Repeats and ALS/FTD

Abstract

Keywords

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