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Ampicillin plus ciprofloxacin therapy of experimental endocarditis caused by multidrug-resistant enterococcus faecium

  • David Landman
  • , John M. Quale
  • , Neville Mobarakai
  • , Mohammad M. Zaman
  • VA Medical Center

Research output: Contribution to journalArticlepeer-review

18 Scopus citations

Abstract

The combination of ampicillin and ciprofloxacin displayed bactericidal in-vitro activity against two strains of Enterococcus faecixan which were highly resistant to ampicillin, vancomycin, and aminoglycosides. This antibiotic combination wasused to treat rabbits with experimental endocarditis caused by these strains. Although a significant decrease in vegetation bacterial counts occurred with one strain, the degree of killing did not approach that of penicillin with an aminoglycoside against susceptible enterococci.

Original languageEnglish
Pages (from-to)253-258
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Volume36
Issue number1
DOIs
StatePublished - Jul 1995

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