An octahedral coordination cage with six Fe(iii) centers as a T1 MRI probe

Aruni Dissanayake; Joseph A. Spernyak; Janet R. Morrow

doi:10.1039/d4cc03681f

An octahedral coordination cage with six Fe(iii) centers as a T₁ MRI probe

Aruni Dissanayake
, Joseph A. Spernyak
, Janet R. Morrow

Chemistry

University at Buffalo

SUNY Buffalo
Roswell Park Cancer Institute

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

The incorporation of multiple Fe(iii) centers bridged by rigid ligands into a coordination cage represents a powerful approach for designing effective MRI contrast agents. In this context, an octahedral coordination cage with six high-spin Fe(iii) centers is shown to be water soluble, robust towards dissociation and has effective relaxivity as a T₁ MRI probe in solution and in mice.

Original language	English
Pages (from-to)	12249-12252
Number of pages	4
Journal	Chemical Communications
Volume	60
Issue number	84
DOIs	https://doi.org/10.1039/d4cc03681f
State	Published - Sep 25 2024

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title = "An octahedral coordination cage with six Fe(iii) centers as a T1 MRI probe",

abstract = "The incorporation of multiple Fe(iii) centers bridged by rigid ligands into a coordination cage represents a powerful approach for designing effective MRI contrast agents. In this context, an octahedral coordination cage with six high-spin Fe(iii) centers is shown to be water soluble, robust towards dissociation and has effective relaxivity as a T1 MRI probe in solution and in mice.",

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AU - Spernyak, Joseph A.

AU - Morrow, Janet R.

PY - 2024/9/25

Y1 - 2024/9/25

N2 - The incorporation of multiple Fe(iii) centers bridged by rigid ligands into a coordination cage represents a powerful approach for designing effective MRI contrast agents. In this context, an octahedral coordination cage with six high-spin Fe(iii) centers is shown to be water soluble, robust towards dissociation and has effective relaxivity as a T1 MRI probe in solution and in mice.

AB - The incorporation of multiple Fe(iii) centers bridged by rigid ligands into a coordination cage represents a powerful approach for designing effective MRI contrast agents. In this context, an octahedral coordination cage with six high-spin Fe(iii) centers is shown to be water soluble, robust towards dissociation and has effective relaxivity as a T1 MRI probe in solution and in mice.

UR - https://www.scopus.com/pages/publications/85205673888

U2 - 10.1039/d4cc03681f

DO - 10.1039/d4cc03681f

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SP - 12249

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JO - Chemical Communications

JF - Chemical Communications

IS - 84

ER -

An octahedral coordination cage with six Fe(iii) centers as a T₁ MRI probe

Abstract

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