Angiotensin II facilitates the potassium-evoked release of 3H-noradrenaline from the rabbit hypothalamus

Jesus A. Garcia-Sevilla; Margarita L. Dubocovich; Salomon Z. Langer

doi:10.1016/0014-2999(79)90449-7

Angiotensin II facilitates the potassium-evoked release of ³H-noradrenaline from the rabbit hypothalamus

Jesus A. Garcia-Sevilla
, Margarita L. Dubocovich
, Salomon Z. Langer

Pharmacology and Toxicology

University at Buffalo

Sanofi-Aventis

Research output: Contribution to journal › Article › peer-review

49 Scopus citations

Abstract

Angiotensin II facilitated in a concentration-dependent manner the potassium-evoked ³H-noradrenaline overflow from the rabbit hypothalamus. This effect which is probably mediated through presynaptic angiotensin facilitatory receptors on noradrenergic nerve terminals was blocked by the specific angiotensin receptor antagonist, saralasin. These results demonstrate that angiotensin II also facilitates the stimulation-evoked release of noradrenaline in the central nervous system.

Original language	English
Pages (from-to)	173-176
Number of pages	4
Journal	European Journal of Pharmacology
Volume	56
Issue number	1-2
DOIs	https://doi.org/10.1016/0014-2999(79)90449-7
State	Published - Jun 1 1979

Keywords

Angiotensin II
Noradrenaline
Presynaptic angiotensin receptors
Rabbit hypothalamus
Saralasin
Transmitter release

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10.1016/0014-2999(79)90449-7

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abstract = "Angiotensin II facilitated in a concentration-dependent manner the potassium-evoked 3H-noradrenaline overflow from the rabbit hypothalamus. This effect which is probably mediated through presynaptic angiotensin facilitatory receptors on noradrenergic nerve terminals was blocked by the specific angiotensin receptor antagonist, saralasin. These results demonstrate that angiotensin II also facilitates the stimulation-evoked release of noradrenaline in the central nervous system.",

keywords = "Angiotensin II, Noradrenaline, Presynaptic angiotensin receptors, Rabbit hypothalamus, Saralasin, Transmitter release",

author = "Garcia-Sevilla, \{Jesus A.\} and Dubocovich, \{Margarita L.\} and Langer, \{Salomon Z.\}",

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AU - Dubocovich, Margarita L.

AU - Langer, Salomon Z.

PY - 1979/6/1

Y1 - 1979/6/1

N2 - Angiotensin II facilitated in a concentration-dependent manner the potassium-evoked 3H-noradrenaline overflow from the rabbit hypothalamus. This effect which is probably mediated through presynaptic angiotensin facilitatory receptors on noradrenergic nerve terminals was blocked by the specific angiotensin receptor antagonist, saralasin. These results demonstrate that angiotensin II also facilitates the stimulation-evoked release of noradrenaline in the central nervous system.

AB - Angiotensin II facilitated in a concentration-dependent manner the potassium-evoked 3H-noradrenaline overflow from the rabbit hypothalamus. This effect which is probably mediated through presynaptic angiotensin facilitatory receptors on noradrenergic nerve terminals was blocked by the specific angiotensin receptor antagonist, saralasin. These results demonstrate that angiotensin II also facilitates the stimulation-evoked release of noradrenaline in the central nervous system.

KW - Angiotensin II

KW - Noradrenaline

KW - Presynaptic angiotensin receptors

KW - Rabbit hypothalamus

KW - Saralasin

KW - Transmitter release

UR - https://www.scopus.com/pages/publications/0018362003

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DO - 10.1016/0014-2999(79)90449-7

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JO - European Journal of Pharmacology

JF - European Journal of Pharmacology

IS - 1-2

ER -

Angiotensin II facilitates the potassium-evoked release of ³H-noradrenaline from the rabbit hypothalamus

Abstract

Keywords

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