Antiangiogenic activity of lupeol from Bombax ceiba

Young Jae You; Nguyen Hai Nam; Yong Kim; Ki Hwan Bae; Byung Zun Ahn

doi:10.1002/ptr.1140

Antiangiogenic activity of lupeol from Bombax ceiba

Young Jae You
, Nguyen Hai Nam
, Yong Kim
, Ki Hwan Bae
, Byung Zun Ahn

Pharmaceutical Sciences

University at Buffalo

Chungnam National University

Research output: Contribution to journal › Article › peer-review

116 Scopus citations

Abstract

In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 μg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.

Original language	English
Pages (from-to)	341-344
Number of pages	4
Journal	Phytotherapy Research
Volume	17
Issue number	4
DOIs	https://doi.org/10.1002/ptr.1140
State	Published - Apr 2003

Keywords

Antiangiogenic activity
Bombax ceiba
Cytotoxicity
Lupeol

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title = "Antiangiogenic activity of lupeol from Bombax ceiba",

abstract = "In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 μg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.",

keywords = "Antiangiogenic activity, Bombax ceiba, Cytotoxicity, Lupeol",

author = "You, \{Young Jae\} and Nam, \{Nguyen Hai\} and Yong Kim and Bae, \{Ki Hwan\} and Ahn, \{Byung Zun\}",

year = "2003",

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doi = "10.1002/ptr.1140",

language = "English",

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T1 - Antiangiogenic activity of lupeol from Bombax ceiba

AU - You, Young Jae

AU - Nam, Nguyen Hai

AU - Kim, Yong

AU - Bae, Ki Hwan

AU - Ahn, Byung Zun

PY - 2003/4

Y1 - 2003/4

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AB - In the search for antiangiogenic agents from medicinal plants used in Vietnam, a methanol extract of the stem barks of Bombax ceiba was found to exhibit a significant antiangiogenic activity on in vitro tube formation of human umbilical venous endothelial cells (HUVEC). Bioactivity-guided fractionation and isolation carried out on this extract afforded lupeol as an active principle. At 50 and 30 μg/mL lupeol showed a marked inhibitory activity on HUVEC tube formation while it did not affect the growth of tumor cell lines such as SK-MEL-2, A549, and B16-F10 melanoma.

KW - Antiangiogenic activity

KW - Bombax ceiba

KW - Cytotoxicity

KW - Lupeol

UR - https://www.scopus.com/pages/publications/0038559958

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DO - 10.1002/ptr.1140

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VL - 17

SP - 341

EP - 344

JO - Phytotherapy Research

JF - Phytotherapy Research

IS - 4

ER -

Antiangiogenic activity of lupeol from Bombax ceiba

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Keywords

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