Antileukemic Activity of Derivatives of 1-Phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole Bis(N-methylcarbamate)

Wayne K. Anderson; Paul F. Corey

doi:10.1021/jm00222a034

Antileukemic Activity of Derivatives of 1-Phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole Bis(N-methylcarbamate)

Wayne K. Anderson
, Paul F. Corey

Pharmaceutical Sciences

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

Treatment of N-aryl-N-acetylalanine derivatives, 3, with acetic anhydride-dimethyl acetylenedicarboxylate gave the dimethyl lV-aryl-2,5-dimethylpyrrole-3,4-dicarboxylates, 4. Reduction of 4 and acylation of 5 gave 2a-j and 6. All of the title compounds 2a-j and 6 showed significant reproducible activity in the P388 in vivo antileukemic assay.

Original language	English
Pages (from-to)	1691-1694
Number of pages	4
Journal	Journal of Medicinal Chemistry
Volume	20
Issue number	12
DOIs	https://doi.org/10.1021/jm00222a034
State	Published - Dec 1 1977

Access to Document

10.1021/jm00222a034

Cite this

@article{f5c7e7f3b4ef4e60a4f52eb7f0ed2ff5,

title = "Antileukemic Activity of Derivatives of 1-Phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole Bis(N-methylcarbamate)",

abstract = "Treatment of N-aryl-N-acetylalanine derivatives, 3, with acetic anhydride-dimethyl acetylenedicarboxylate gave the dimethyl lV-aryl-2,5-dimethylpyrrole-3,4-dicarboxylates, 4. Reduction of 4 and acylation of 5 gave 2a-j and 6. All of the title compounds 2a-j and 6 showed significant reproducible activity in the P388 in vivo antileukemic assay.",

author = "Anderson, \{Wayne K.\} and Corey, \{Paul F.\}",

year = "1977",

month = dec,

day = "1",

doi = "10.1021/jm00222a034",

language = "English",

volume = "20",

pages = "1691--1694",

journal = "Journal of Medicinal Chemistry",

issn = "0022-2623",

publisher = "American Chemical Society",

number = "12",

}

TY - JOUR

T1 - Antileukemic Activity of Derivatives of 1-Phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole Bis(N-methylcarbamate)

AU - Anderson, Wayne K.

AU - Corey, Paul F.

PY - 1977/12/1

Y1 - 1977/12/1

N2 - Treatment of N-aryl-N-acetylalanine derivatives, 3, with acetic anhydride-dimethyl acetylenedicarboxylate gave the dimethyl lV-aryl-2,5-dimethylpyrrole-3,4-dicarboxylates, 4. Reduction of 4 and acylation of 5 gave 2a-j and 6. All of the title compounds 2a-j and 6 showed significant reproducible activity in the P388 in vivo antileukemic assay.

AB - Treatment of N-aryl-N-acetylalanine derivatives, 3, with acetic anhydride-dimethyl acetylenedicarboxylate gave the dimethyl lV-aryl-2,5-dimethylpyrrole-3,4-dicarboxylates, 4. Reduction of 4 and acylation of 5 gave 2a-j and 6. All of the title compounds 2a-j and 6 showed significant reproducible activity in the P388 in vivo antileukemic assay.

UR - https://www.scopus.com/pages/publications/0017707205

U2 - 10.1021/jm00222a034

DO - 10.1021/jm00222a034

M3 - Article

C2 - 592338

SN - 0022-2623

VL - 20

SP - 1691

EP - 1694

JO - Journal of Medicinal Chemistry

JF - Journal of Medicinal Chemistry

IS - 12

ER -

Antileukemic Activity of Derivatives of 1-Phenyl-2,5-dimethyl-3,4-bis(hydroxymethyl)pyrrole Bis(N-methylcarbamate)

Abstract

Access to Document

Other files and links

Fingerprint

Cite this