Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder

Kenneth D. Gadow; Jasmin Roohi; Carla J. Devincent; Sarah Kirsch; Eli Hatchwell

doi:10.1007/s10803-009-0794-4

Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder

Kenneth D. Gadow
, Jasmin Roohi
, Carla J. Devincent
, Sarah Kirsch
, Eli Hatchwell

Psychiatry

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

65 Scopus citations

Abstract

The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp² = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp ² = 0.10) and teacher-rated tics (p = 0.04; ηp ² = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp ² = 0.09) of BDNF genotype with DAT1 3VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.

Original language	English
Pages (from-to)	1542-1551
Number of pages	10
Journal	Journal of Autism and Developmental Disorders
Volume	39
Issue number	11
DOIs	https://doi.org/10.1007/s10803-009-0794-4
State	Published - Nov 2009

Keywords

Anxiety
Attention-deficit hyperactivity disorder
Autism
Autism spectrum disorder
BDNF
COMT
DAT1
Tourette syndrome

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10.1007/s10803-009-0794-4

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title = "Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder",

abstract = "The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.",

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author = "Gadow, \{Kenneth D.\} and Jasmin Roohi and Devincent, \{Carla J.\} and Sarah Kirsch and Eli Hatchwell",

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AU - Roohi, Jasmin

AU - Devincent, Carla J.

AU - Kirsch, Sarah

AU - Hatchwell, Eli

PY - 2009/11

Y1 - 2009/11

N2 - The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.

AB - The aim of the study is to examine rs4680 (COMT) and rs6265 (BDNF) as genetic markers of anxiety, ADHD, and tics. Parents and teachers completed a DSM-IV-referenced rating scale for a total sample of 67 children with autism spectrum disorder (ASD). Both COMT (p = 0.06) and BDNF (p = 0.07) genotypes were marginally significant for teacher ratings of social phobia (ηp2 = 0.06). Analyses also indicated associations of BDNF genotype with parent-rated ADHD (p = 0.01, ηp 2 = 0.10) and teacher-rated tics (p = 0.04; ηp 2 = 0.07). There was also evidence of a possible interaction (p = 0.02, ηp 2 = 0.09) of BDNF genotype with DAT1 3VNTR with tic severity. BDNF and COMT may be biomarkers for phenotypic variation in ASD, but these preliminary findings remain tentative pending replication with larger, independent samples.

KW - Anxiety

KW - Attention-deficit hyperactivity disorder

KW - Autism

KW - Autism spectrum disorder

KW - BDNF

KW - COMT

KW - DAT1

KW - Tourette syndrome

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DO - 10.1007/s10803-009-0794-4

M3 - Article

C2 - 19582565

SN - 0162-3257

VL - 39

SP - 1542

EP - 1551

JO - Journal of Autism and Developmental Disorders

JF - Journal of Autism and Developmental Disorders

IS - 11

ER -

Association of COMT (Val158Met) and BDNF (Val66Met) gene polymorphisms with anxiety, ADHD and tics in children with autism spectrum disorder

Abstract

Keywords

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