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Big data analysis of energy landscape dynamical sampling using elastic network model eigenvectors

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

Proteins are large complex biomolecules which have structural vibrations in the terahertz range. The vibrational spectrum is dependent on the protein structure, which fluctuates at biological temperatures. Recently it was shown that these fluctuations can be accounted for by massive sampling of the energy landscape to calculate the terahertz isotropic and anisotropic absorbance. The large number of vibrations contributing to the spectra however makes interpretation of resonant bands challenging. Here we examine how we can apply elastic network models to define fundamental vibrational displacements to analyze these massive data sets.

Original languageEnglish
Title of host publication2020 45th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2020
PublisherIEEE Computer Society
Pages740
Number of pages1
ISBN (Electronic)9781728166209
DOIs
StatePublished - Nov 8 2020
Event45th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2020 - Virtual, Buffalo, United States
Duration: Nov 8 2020Nov 13 2020

Publication series

NameInternational Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz
Volume2020-November

Conference

Conference45th International Conference on Infrared, Millimeter, and Terahertz Waves, IRMMW-THz 2020
Country/TerritoryUnited States
CityVirtual, Buffalo
Period11/8/2011/13/20

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