Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang; Weiguo Cao; Honglin Jin; Jonathan F. Lovell; Mi Yang; Lili Ding; Juan Chen; Ian Corbin; Qingming Luo; Gang Zheng

doi:10.1002/anie.200903112

Biomimetic nanocarrier for direct cytosolic drug delivery

Zhihong Zhang
, Weiguo Cao
, Honglin Jin
, Jonathan F. Lovell
, Mi Yang
, Lili Ding
, Juan Chen
, Ian Corbin
, Qingming Luo
, Gang Zheng

Department of Biomedical Engineering

University at Buffalo

University of Toronto
Huazhong University of Science and Technology
Shanghai University

Research output: Contribution to journal › Article › peer-review

153 Scopus citations

Abstract

Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

Original language	English
Pages (from-to)	9171-9175
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	48
DOIs	https://doi.org/10.1002/anie.200903112
State	Published - Nov 16 2009

Keywords

Biomimetic structures
Cytosol
Drug delivery
Nanocarriers
Peptides

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10.1002/anie.200903112

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abstract = "Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).",

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AU - Zhang, Zhihong

AU - Cao, Weiguo

AU - Jin, Honglin

AU - Lovell, Jonathan F.

AU - Yang, Mi

AU - Ding, Lili

AU - Chen, Juan

AU - Corbin, Ian

AU - Luo, Qingming

AU - Zheng, Gang

PY - 2009/11/16

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AB - Getting straight to the point: A peptide-phospholipid-based biomimetic nanocarrier was developed that can transport cargo molecules directly into cytosolic compartments through a non-endocytotic uptake mechanism mediated by scavenger receptor class B type I (SR-BI ; see schematic illustration). The fluorescent image shows the cytosolic localization of a dye (red) delivered by the nanocarrier to SR-BI-positive cells (nuclei: blue, membranes: cyan).

KW - Biomimetic structures

KW - Cytosol

KW - Drug delivery

KW - Nanocarriers

KW - Peptides

UR - https://www.scopus.com/pages/publications/70449568243

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JF - Angewandte Chemie - International Edition

IS - 48

ER -

Biomimetic nanocarrier for direct cytosolic drug delivery

Abstract

Keywords

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