TY - GEN
T1 - Blending alginate with hydrophohically enhanced cellulose for drug release studies
AU - White, Joe
AU - Choudhary, Soumitra
AU - Bhatia, Surita
PY - 2009
Y1 - 2009
N2 - Research has shown how useful alginate, a natural polymer found in brown algae, is in drug delivery engineering. However, the addition of various substances that form gel networks with alginate improves the mechanical properties of the gels formed. This study examines how gels from alginate and cellulose behave mechanically to determine which cellulose shows the best improvement for future drug delivery research. Mechanical properties studied include swelling, gelation, and rheological characteristics. Hydrophobically enhanced ethyl hydroxyethyl cellulose (EHEC) with various degrees of polymerization was used in the study. Higher concentrations of cellulose in the mixture yielded more solid-like behavior from the alginate-EHEC gel networks. With the improvement of mechanical durability of drug encapsulation substances, longer lasting drug release can be used to reduce frequency of dosage per medication.
AB - Research has shown how useful alginate, a natural polymer found in brown algae, is in drug delivery engineering. However, the addition of various substances that form gel networks with alginate improves the mechanical properties of the gels formed. This study examines how gels from alginate and cellulose behave mechanically to determine which cellulose shows the best improvement for future drug delivery research. Mechanical properties studied include swelling, gelation, and rheological characteristics. Hydrophobically enhanced ethyl hydroxyethyl cellulose (EHEC) with various degrees of polymerization was used in the study. Higher concentrations of cellulose in the mixture yielded more solid-like behavior from the alginate-EHEC gel networks. With the improvement of mechanical durability of drug encapsulation substances, longer lasting drug release can be used to reduce frequency of dosage per medication.
UR - https://www.scopus.com/pages/publications/70349141863
U2 - 10.1109/NEBC.2009.4967757
DO - 10.1109/NEBC.2009.4967757
M3 - Conference contribution
SN - 9781424443628
T3 - Proceedings of the IEEE Annual Northeast Bioengineering Conference, NEBEC
BT - NEBEC 2009 - Proceedings of the IEEE 35th Annual Northeast Bioengineering Conference
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - IEEE 35th Annual Northeast Bioengineering Conference, NEBEC 2009
Y2 - 3 April 2009 through 5 April 2009
ER -