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BoneNET: A network model of bone microstructure and dynamics

  • SUNY Buffalo

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

We develop a network model of bone microstructure and dynamics, BoneNET, which is capable of quantitative assessment of Bone Mineral Density (BMD) and bone remodelling dynamics. First, we introduce a network model of bone microstructure by describing structural properties and process of bone network modelling. Secondly, we explain a mathematical model of bone microstructure by analysing the density for mineralised fibres of bone microstructure. Finally, we provide a bone remodelling dynamics among osteoblast and osteoclast and study bone networks by proposing several measurements to calculate bone strength and identify critical elements in bone microstructure.

Original languageEnglish
Pages (from-to)123-149
Number of pages27
JournalInternational Journal of Data Mining and Bioinformatics
Volume8
Issue number2
DOIs
StatePublished - 2013

Keywords

  • BMD
  • Bone mineral density
  • Bone remodelling dynamics
  • Bone strength
  • Computational model of bone microstructure
  • Osteoporosis.

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