Brain pH in migraine: An in vivo phosphorus-31 magnetic resonance spectroscopy study

K. M.A. Welch; Steven R. Levine; Giovanni D'Andrea; J. A. Helpern

doi:10.1046/j.1468-2982.1988.0804273.x

Brain pH in migraine: An in vivo phosphorus-31 magnetic resonance spectroscopy study

K. M.A. Welch
, Steven R. Levine
, Giovanni D'Andrea
, J. A. Helpern

Neurology

SUNY Downstate Health Sciences University

Henry Ford Health System
Vicenza Hospital
Oakland University

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

The intracellular pH (pH_i) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pH_i were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.

Original language	English
Pages (from-to)	273-277
Number of pages	5
Journal	Cephalalgia : an international journal of headache
Volume	8
Issue number	4
DOIs	https://doi.org/10.1046/j.1468-2982.1988.0804273.x
State	Published - Dec 1988

Keywords

Magnetic resonance spectroscopy
migraine
pH
phosphorus-31

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10.1046/j.1468-2982.1988.0804273.x

Cite this

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title = "Brain pH in migraine: An in vivo phosphorus-31 magnetic resonance spectroscopy study",

abstract = "The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.",

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AU - D'Andrea, Giovanni

AU - Helpern, J. A.

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N2 - The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.

AB - The intracellular pH (pHi) of cerebral cortex was measured in migraine patients by use of in vivo phosphorus-31 NMR spectroscopy. No changes in pHi were measured during a migraine attack. The long-standing concept that the headache of migraine is due to cerebral vaso-dilatation induced by prodromal vasospasm-induced ischemic acidosis is not substantiated.

KW - Magnetic resonance spectroscopy

KW - migraine

KW - pH

KW - phosphorus-31

UR - https://www.scopus.com/pages/publications/0024252921

U2 - 10.1046/j.1468-2982.1988.0804273.x

DO - 10.1046/j.1468-2982.1988.0804273.x

M3 - Article

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SN - 0333-1024

VL - 8

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JO - Cephalalgia : an international journal of headache

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ER -

Brain pH in migraine: An in vivo phosphorus-31 magnetic resonance spectroscopy study

Abstract

Keywords

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