Bringing stereoselectivity to C(sp3)–H nucleophilic fluorination

Kalen B. Laybourn; Patricia Z. Musacchio

doi:10.1016/j.checat.2025.101568

Bringing stereoselectivity to C(sp³)–H nucleophilic fluorination

Kalen B. Laybourn
, Patricia Z. Musacchio

Chemistry

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Comment/debate

Abstract

Reporting in Nature Catalysis , Yu and colleagues have achieved an enantioselective C(sp³)–H fluorination of amides by using Pd catalysis, chiral amino-acid-derived ligands, and nucleophilic fluoride sources.

Original language	English
Article number	101568
Journal	Chem Catalysis
Volume	5
Issue number	11
DOIs	https://doi.org/10.1016/j.checat.2025.101568
State	Published - Nov 20 2025

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10.1016/j.checat.2025.101568

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title = "Bringing stereoselectivity to C(sp3)–H nucleophilic fluorination",

abstract = "Reporting in Nature Catalysis , Yu and colleagues have achieved an enantioselective C(sp3)–H fluorination of amides by using Pd catalysis, chiral amino-acid-derived ligands, and nucleophilic fluoride sources.",

author = "Laybourn, \{Kalen B.\} and Musacchio, \{Patricia Z.\}",

note = "Publisher Copyright: {\textcopyright} 2025 Elsevier Inc.",

year = "2025",

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day = "20",

doi = "10.1016/j.checat.2025.101568",

language = "English",

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journal = "Chem Catalysis",

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T1 - Bringing stereoselectivity to C(sp3)–H nucleophilic fluorination

AU - Laybourn, Kalen B.

AU - Musacchio, Patricia Z.

PY - 2025/11/20

Y1 - 2025/11/20

N2 - Reporting in Nature Catalysis , Yu and colleagues have achieved an enantioselective C(sp3)–H fluorination of amides by using Pd catalysis, chiral amino-acid-derived ligands, and nucleophilic fluoride sources.

AB - Reporting in Nature Catalysis , Yu and colleagues have achieved an enantioselective C(sp3)–H fluorination of amides by using Pd catalysis, chiral amino-acid-derived ligands, and nucleophilic fluoride sources.

UR - https://www.scopus.com/pages/publications/105022067155

U2 - 10.1016/j.checat.2025.101568

DO - 10.1016/j.checat.2025.101568

M3 - Comment/debate

SN - 2667-1107

VL - 5

JO - Chem Catalysis

JF - Chem Catalysis

IS - 11

M1 - 101568

ER -

Bringing stereoselectivity to C(sp³)–H nucleophilic fluorination

Abstract

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