Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides

Eriks Rozners; Erika Bizdena

doi:10.1080/15257779508010720

Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides

Eriks Rozners
, Erika Bizdena

Chemistry

Binghamton University

Riga Technical University

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

: A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2’-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers.

Original language	English
Pages (from-to)	2009-2025
Number of pages	17
Journal	Nucleosides and Nucleotides
Volume	14
Issue number	9-10
DOIs	https://doi.org/10.1080/15257779508010720
State	Published - Nov 1 1995

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10.1080/15257779508010720

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title = "Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides",

abstract = ": A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2{\textquoteright}-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers.",

author = "Eriks Rozners and Erika Bizdena",

year = "1995",

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doi = "10.1080/15257779508010720",

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T1 - Building Blocks for Synthesis of Oligoarabinonucleotides

T2 - Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides

AU - Rozners, Eriks

AU - Bizdena, Erika

PY - 1995/11/1

Y1 - 1995/11/1

N2 - : A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2’-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers.

AB - : A straightforward and inexpensive synthesis of arabinonucleoside H-phosphonates has been developed. Arabinonucleosides were synthesised from protected ribonucleosides via 2’-keto derivatives. Reaction conditions have been optimised for compounds bearing labile N-protections. Further protecting group manipulation and phosphonylation gave the required H-phosphonate monomers.

UR - https://www.scopus.com/pages/publications/0029585079

U2 - 10.1080/15257779508010720

DO - 10.1080/15257779508010720

M3 - Article

SN - 0732-8311

VL - 14

SP - 2009

EP - 2025

JO - Nucleosides and Nucleotides

JF - Nucleosides and Nucleotides

IS - 9-10

ER -

Building Blocks for Synthesis of Oligoarabinonucleotides: Preparation of Arabinonucleoside H-Phosphonates from Protected Ribonucleosides

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