Calcitonin effects on isolated bone cells

M. Shlossman; M. Brown; E. Shapiro; R. Dziak

doi:10.1007/BF02411232

Calcitonin effects on isolated bone cells

M. Shlossman
, M. Brown
, E. Shapiro
, R. Dziak

Department of Oral Biology

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

39 Scopus citations

Abstract

Calcitonin decreased calcium uptake in specific rat bone cell populations obtained by sequential collagenase digestions of calvaria. The calcitonin effect on calcium uptake was observed in the same populations that manifested calcitonin-induced increases in cyclic AMP as well as high levels of acid phosphatase and the ability to release⁴⁵Ca from prelabeled devitalized bone. No effect of calcitonin was observed in cell populations that had high levels of alkaline phosphatase and lacked the potential to resorb devitalized bone. These results suggest that changes in cell calcium as well as cyclic AMP may be involved in the mode of action of calcitonin on osteoclast-like cells.

Original language	English
Pages (from-to)	190-196
Number of pages	7
Journal	Calcified Tissue International
Volume	34
Issue number	1
DOIs	https://doi.org/10.1007/BF02411232
State	Published - Dec 1982

Keywords

Bone cells
Calcitonin
Cyclic AMP

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10.1007/BF02411232

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title = "Calcitonin effects on isolated bone cells",

abstract = "Calcitonin decreased calcium uptake in specific rat bone cell populations obtained by sequential collagenase digestions of calvaria. The calcitonin effect on calcium uptake was observed in the same populations that manifested calcitonin-induced increases in cyclic AMP as well as high levels of acid phosphatase and the ability to release45Ca from prelabeled devitalized bone. No effect of calcitonin was observed in cell populations that had high levels of alkaline phosphatase and lacked the potential to resorb devitalized bone. These results suggest that changes in cell calcium as well as cyclic AMP may be involved in the mode of action of calcitonin on osteoclast-like cells.",

keywords = "Bone cells, Calcitonin, Cyclic AMP",

author = "M. Shlossman and M. Brown and E. Shapiro and R. Dziak",

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T1 - Calcitonin effects on isolated bone cells

AU - Shlossman, M.

AU - Brown, M.

AU - Shapiro, E.

AU - Dziak, R.

PY - 1982/12

Y1 - 1982/12

N2 - Calcitonin decreased calcium uptake in specific rat bone cell populations obtained by sequential collagenase digestions of calvaria. The calcitonin effect on calcium uptake was observed in the same populations that manifested calcitonin-induced increases in cyclic AMP as well as high levels of acid phosphatase and the ability to release45Ca from prelabeled devitalized bone. No effect of calcitonin was observed in cell populations that had high levels of alkaline phosphatase and lacked the potential to resorb devitalized bone. These results suggest that changes in cell calcium as well as cyclic AMP may be involved in the mode of action of calcitonin on osteoclast-like cells.

AB - Calcitonin decreased calcium uptake in specific rat bone cell populations obtained by sequential collagenase digestions of calvaria. The calcitonin effect on calcium uptake was observed in the same populations that manifested calcitonin-induced increases in cyclic AMP as well as high levels of acid phosphatase and the ability to release45Ca from prelabeled devitalized bone. No effect of calcitonin was observed in cell populations that had high levels of alkaline phosphatase and lacked the potential to resorb devitalized bone. These results suggest that changes in cell calcium as well as cyclic AMP may be involved in the mode of action of calcitonin on osteoclast-like cells.

KW - Bone cells

KW - Calcitonin

KW - Cyclic AMP

UR - https://www.scopus.com/pages/publications/0020472414

U2 - 10.1007/BF02411232

DO - 10.1007/BF02411232

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VL - 34

SP - 190

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JO - Calcified Tissue International

JF - Calcified Tissue International

IS - 1

ER -

Calcitonin effects on isolated bone cells

Abstract

Keywords

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