Cell transplantation for stroke

Sean I. Savitz; Daniel M. Rosenbaum; Jonathan H. Dinsmore; Lawrence R. Wechsler; Louis R. Caplan

doi:10.1002/ana.60000

Cell transplantation for stroke

Sean I. Savitz
, Daniel M. Rosenbaum
, Jonathan H. Dinsmore
, Lawrence R. Wechsler
, Louis R. Caplan

Neurology

SUNY Downstate Health Sciences University

Research output: Contribution to journal › Article › peer-review

122 Scopus citations

Abstract

Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion.

Original language	English
Pages (from-to)	266-275
Number of pages	10
Journal	Annals of Neurology
Volume	52
Issue number	3
DOIs	https://doi.org/10.1002/ana.60000
State	Published - Sep 2002

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title = "Cell transplantation for stroke",

abstract = "Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion.",

author = "Savitz, \{Sean I.\} and Rosenbaum, \{Daniel M.\} and Dinsmore, \{Jonathan H.\} and Wechsler, \{Lawrence R.\} and Caplan, \{Louis R.\}",

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AU - Rosenbaum, Daniel M.

AU - Dinsmore, Jonathan H.

AU - Wechsler, Lawrence R.

AU - Caplan, Louis R.

PY - 2002/9

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N2 - Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion.

AB - Cell transplantation has emerged as an experimental approach to restore brain function after stroke. Various cell types including porcine fetal cells, stem cells, immortalized cell lines, and marrow stromal cells are under investigation in experimental and clinical stroke trials. This review discusses the unique advantages and limitations of the different graft sources and emphasizes the current, limited knowledge about their biology. The survival, integration, and efficacy of neural transplants in stroke patients will depend on the type, severity, chronicity, adequacy of circulation, and location of the stroke lesion.

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DO - 10.1002/ana.60000

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JO - Annals of Neurology

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ER -

Cell transplantation for stroke

Abstract

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