Characterization of 4-aminopyridine in overdose

Christine M. Stork; Robert S. Hoffman

doi:10.3109/15563659409011063

Characterization of 4-aminopyridine in overdose

Christine M. Stork
, Robert S. Hoffman

Pharmacology

Upstate Medical University

New York City Health and Hospitals Corporation
New York University

Research output: Contribution to journal › Article › peer-review

58 Scopus citations

Abstract

We report three cases of 4-aminopyridine overdose resulting in seizure activity. All patients were on therapeutic regimens for the treatment of multiple sclerosis. All patients were responsive to intensive supportive care, although the length of toxicity was prolonged more than 24 hours in one patient. Seizure activity was responsive to benzodiazepine and phenytoin therapy.

Original language	English
Pages (from-to)	583-587
Number of pages	5
Journal	Clinical Toxicology
Volume	32
Issue number	5
DOIs	https://doi.org/10.3109/15563659409011063
State	Published - 1994

Keywords

Aminopyridine
Human
Poisoning

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10.3109/15563659409011063

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title = "Characterization of 4-aminopyridine in overdose",

abstract = "We report three cases of 4-aminopyridine overdose resulting in seizure activity. All patients were on therapeutic regimens for the treatment of multiple sclerosis. All patients were responsive to intensive supportive care, although the length of toxicity was prolonged more than 24 hours in one patient. Seizure activity was responsive to benzodiazepine and phenytoin therapy.",

keywords = "Aminopyridine, Human, Poisoning",

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AU - Hoffman, Robert S.

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AB - We report three cases of 4-aminopyridine overdose resulting in seizure activity. All patients were on therapeutic regimens for the treatment of multiple sclerosis. All patients were responsive to intensive supportive care, although the length of toxicity was prolonged more than 24 hours in one patient. Seizure activity was responsive to benzodiazepine and phenytoin therapy.

KW - Aminopyridine

KW - Human

KW - Poisoning

UR - https://www.scopus.com/pages/publications/0028148351

U2 - 10.3109/15563659409011063

DO - 10.3109/15563659409011063

M3 - Article

C2 - 7932918

SN - 1556-3650

VL - 32

SP - 583

EP - 587

JO - Clinical Toxicology

JF - Clinical Toxicology

IS - 5

ER -

Characterization of 4-aminopyridine in overdose

Abstract

Keywords

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