@inbook{196927441fa04299819bf382d2d4c856,
title = "Characterization of arsenic-induced cancer stem-like cells",
abstract = "Arsenic is a well-known human carcinogen. However, the mechanisms underlying arsenic-induced carcinogenesis remain elusive. Here we show that chronic and low level of arsenic stress induces transformation of the human bronchial epithelial cells, BEAS-2B, and that some of the transformed cells show characteristics of cancer stem-like cells (CSCs). Meanwhile, we demonstrate that arsenic stress dedifferentiates CD61+ BEAS-2B cells into CSC-like CD61− cells featured with noncanonical epithelial–mesenchymal transition (EMT), enhanced chemoresistance, and metastasis. Finally, we show that oncogene c-Myc expression is associated with arsenic-induced tumor initiation and progression. Altogether, our findings highlight a unique mechanism of arsenic-induced transformation of human bronchial epithelial cells and provide a novel therapeutic target for arsenic-initiated lung cancer.",
keywords = "Arsenic, Cancer, Cancer stem cells, Environment, Transformation",
author = "Qingshan Chang and Zhuoyue Bi and Yao Fu and Rice, \{M{\textquoteright} Kya Anique\} and Qian Zhang and Priya Wadgaonkar and Bandar Almutairy and Wenxian Zhang and Yongju Lu and Liping Xu and Chitra Thukar and Fei Chen",
note = "Publisher Copyright: {\textcopyright} 2020, Springer Science+Business Media, LLC, part of Springer Nature.",
year = "2020",
doi = "10.1007/978-1-0716-0301-7\_19",
language = "English",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "293--303",
booktitle = "Methods in Molecular Biology",
}