Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis

Elizabeth A. Ruckdeschel; Aimee L. Brauer; Antoinette Johnson; Timothy F. Murphy

doi:10.1016/j.vaccine.2009.09.062

Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis

Elizabeth A. Ruckdeschel
, Aimee L. Brauer
, Antoinette Johnson
, Timothy F. Murphy

Medicine

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M. catarrhalis. Vaccine formulations individually administered subcutaneously and intranasally showed enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model by both routes of administration. Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis.

Original language	English
Pages (from-to)	7065-7072
Number of pages	8
Journal	Vaccine
Volume	27
Issue number	50
DOIs	https://doi.org/10.1016/j.vaccine.2009.09.062
State	Published - Nov 23 2009

Keywords

Immunization
Moraxella catarrhalis
Mouse pulmonary clearance
Obstructive lung disease
Otitis media
Vaccine

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10.1016/j.vaccine.2009.09.062

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title = "Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis",

abstract = "Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M. catarrhalis. Vaccine formulations individually administered subcutaneously and intranasally showed enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model by both routes of administration. Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis.",

keywords = "Immunization, Moraxella catarrhalis, Mouse pulmonary clearance, Obstructive lung disease, Otitis media, Vaccine",

author = "Ruckdeschel, \{Elizabeth A.\} and Brauer, \{Aimee L.\} and Antoinette Johnson and Murphy, \{Timothy F.\}",

year = "2009",

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day = "23",

doi = "10.1016/j.vaccine.2009.09.062",

language = "English",

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TY - JOUR

T1 - Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis

AU - Ruckdeschel, Elizabeth A.

AU - Brauer, Aimee L.

AU - Johnson, Antoinette

AU - Murphy, Timothy F.

PY - 2009/11/23

Y1 - 2009/11/23

N2 - Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M. catarrhalis. Vaccine formulations individually administered subcutaneously and intranasally showed enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model by both routes of administration. Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis.

AB - Moraxella catarrhalis is a respiratory tract pathogen causing otitis media in children and respiratory tract infections in adults with chronic obstructive pulmonary disease. This study examined two newly identified proteins as potential vaccine antigens. Antisera raised to recombinant purified proteins Msp22 and Msp75 recognized corresponding native proteins in multiple strains of M. catarrhalis. Vaccine formulations individually administered subcutaneously and intranasally showed enhanced clearance of M. catarrhalis in a mouse pulmonary clearance model by both routes of administration. Msp22 and Msp75 are antigenically conserved proteins that induce potentially protective immune responses and should be examined further as vaccine antigens for M. catarrhalis.

KW - Immunization

KW - Moraxella catarrhalis

KW - Mouse pulmonary clearance

KW - Obstructive lung disease

KW - Otitis media

KW - Vaccine

UR - https://www.scopus.com/pages/publications/70350575318

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DO - 10.1016/j.vaccine.2009.09.062

M3 - Article

C2 - 19786139

SN - 0264-410X

VL - 27

SP - 7065

EP - 7072

JO - Vaccine

JF - Vaccine

IS - 50

ER -

Characterization of proteins Msp22 and Msp75 as vaccine antigens of Moraxella catarrhalis

Abstract

Keywords

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