Click and photo-release dual-functional nucleic acid nanostructures

Vibhav A. Valsangkar; Arun Richard Chandrasekaran; Lifeng Zhuo; Song Mao; Goh Woon Lee; Megan Kizer; Xing Wang; Ken Halvorsen; Jia Sheng

doi:10.1039/c9cc03806j

Click and photo-release dual-functional nucleic acid nanostructures

Vibhav A. Valsangkar
, Arun Richard Chandrasekaran
, Lifeng Zhuo
, Song Mao
, Goh Woon Lee
, Megan Kizer
, Xing Wang
, Ken Halvorsen
, Jia Sheng

University at Albany

SUNY Albany
Rensselaer Polytechnic Institute

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

Original language	English
Pages (from-to)	9709-9712
Number of pages	4
Journal	Chemical Communications
Volume	55
Issue number	65
DOIs	https://doi.org/10.1039/c9cc03806j
State	Published - 2019

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title = "Click and photo-release dual-functional nucleic acid nanostructures",

abstract = "We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.",

author = "Valsangkar, \{Vibhav A.\} and Chandrasekaran, \{Arun Richard\} and Lifeng Zhuo and Song Mao and Lee, \{Goh Woon\} and Megan Kizer and Xing Wang and Ken Halvorsen and Jia Sheng",

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T1 - Click and photo-release dual-functional nucleic acid nanostructures

AU - Valsangkar, Vibhav A.

AU - Chandrasekaran, Arun Richard

AU - Zhuo, Lifeng

AU - Mao, Song

AU - Lee, Goh Woon

AU - Kizer, Megan

AU - Wang, Xing

AU - Halvorsen, Ken

AU - Sheng, Jia

PY - 2019

Y1 - 2019

N2 - We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

AB - We functionalize nucleic acid nanostructures with click chemistry (for attachment of cargos) and a photocleavable linker (for release). We demonstrate cargo attachment using a fluorescein dye and release using UV trigger from an RNA three-way junction, a DNA star motif and a DNA tetrahedron. Such multifunctional nucleic acid nanostructures have potential in targeted drug delivery.

UR - https://www.scopus.com/pages/publications/85070473065

U2 - 10.1039/c9cc03806j

DO - 10.1039/c9cc03806j

M3 - Article

C2 - 31353371

SN - 1359-7345

VL - 55

SP - 9709

EP - 9712

JO - Chemical Communications

JF - Chemical Communications

IS - 65

ER -

Click and photo-release dual-functional nucleic acid nanostructures

Abstract

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