Complexes trans-[RuCl2(nic)4] and trans-[RuCl2(i-nic)4] as free radical scavengers

Tânia B. Creczynski-Pasa; Vilson R. Bonetti; Alessandra Beirith; Karina Ckless; Marlon Konzen; Ilana Seifriz; Marcos S. Paula; Cesar V. Franco; Danilo Wilhelm Wilhelm Filho; João B. Calixto

doi:10.1016/S0162-0134(01)00222-7

Complexes trans-[RuCl₂(nic)₄] and trans-[RuCl₂(i-nic)₄] as free radical scavengers

Tânia B. Creczynski-Pasa
, Vilson R. Bonetti
, Alessandra Beirith
, Karina Ckless
, Marlon Konzen
, Ilana Seifriz
, Marcos S. Paula
, Cesar V. Franco
, Danilo Wilhelm Wilhelm Filho
, João B. Calixto

Chemistry and Biochemistry

SUNY Plattsburgh

Universidade Federal de Santa Catarina

Research output: Contribution to journal › Article › peer-review

15 Scopus citations

Abstract

This study evaluates the action of the new ruthenium complexes trans-RuCl₂(nic)₄] (I) and trans-[RuCl₂(i-nic)₄] (II) as free radical scavengers. In our experiments, both compounds acted as scavengers of superoxide anion (O₂^˙−), hydroxyl radicals (HO^˙) and nitrogen monoxide (formally known as 'nitric oxide'; NO^˙). In addition, complexes I and II potentiated the release of NO^˙ from S-nitroso-N-acetyl-DL-penicilamine (SNAP), a NO^˙ donor. Complex II, but not I, also decreased the nitrite levels in culture media of activated macrophages. A hypsochromic shift of λ_max and a significant change in half-wave potential (E_1/2) was observed when NO^˙ was added to the Complex II. Thiobarbituric reactive substance (TBARS) levels were significantly reduced in rats treated for 1 week with Complex II plus tert-butylhydroperoxide, when compared to rats treated only with tert-butylhydroperoxide. None of the complexes showed cytotoxicity. These findings support the suggestion that the new ruthenium complexes, especially trans-[RuCl₂(i-nic)₄] or its derivatives, might provide potential therapeutic benefits in disorders where reactive nitrogen (RNS) or oxygen (ROS) species are involved.

Original language	English
Pages (from-to)	587-594
Number of pages	8
Journal	Journal of Inorganic Biochemistry
Volume	86
Issue number	2-3
DOIs	https://doi.org/10.1016/S0162-0134(01)00222-7
State	Published - 2001

Keywords

Antioxidant
Free radical scavenger
Hydroxyl radical
Nitric oxide
Nitrogen monoxide
Ruthenium complex
Superoxide anion radical

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10.1016/S0162-0134(01)00222-7

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title = "Complexes trans-[RuCl2(nic)4] and trans-[RuCl2(i-nic)4] as free radical scavengers",

abstract = "This study evaluates the action of the new ruthenium complexes trans-RuCl2(nic)4] (I) and trans-[RuCl2(i-nic)4] (II) as free radical scavengers. In our experiments, both compounds acted as scavengers of superoxide anion (O2˙−), hydroxyl radicals (HO˙) and nitrogen monoxide (formally known as 'nitric oxide'; NO˙). In addition, complexes I and II potentiated the release of NO˙ from S-nitroso-N-acetyl-DL-penicilamine (SNAP), a NO˙ donor. Complex II, but not I, also decreased the nitrite levels in culture media of activated macrophages. A hypsochromic shift of λmax and a significant change in half-wave potential (E1/2) was observed when NO˙ was added to the Complex II. Thiobarbituric reactive substance (TBARS) levels were significantly reduced in rats treated for 1 week with Complex II plus tert-butylhydroperoxide, when compared to rats treated only with tert-butylhydroperoxide. None of the complexes showed cytotoxicity. These findings support the suggestion that the new ruthenium complexes, especially trans-[RuCl2(i-nic)4] or its derivatives, might provide potential therapeutic benefits in disorders where reactive nitrogen (RNS) or oxygen (ROS) species are involved.",

keywords = "Antioxidant, Free radical scavenger, Hydroxyl radical, Nitric oxide, Nitrogen monoxide, Ruthenium complex, Superoxide anion radical",

author = "Creczynski-Pasa, \{T{\^a}nia B.\} and Bonetti, \{Vilson R.\} and Alessandra Beirith and Karina Ckless and Marlon Konzen and Ilana Seifriz and Paula, \{Marcos S.\} and Franco, \{Cesar V.\} and \{Wilhelm Filho\}, \{Danilo Wilhelm\} and Calixto, \{Jo{\~a}o B.\}",

year = "2001",

doi = "10.1016/S0162-0134(01)00222-7",

language = "English",

volume = "86",

pages = "587--594",

journal = "Journal of Inorganic Biochemistry",

issn = "0162-0134",

publisher = "Elsevier Inc.",

number = "2-3",

}

TY - JOUR

T1 - Complexes trans-[RuCl2(nic)4] and trans-[RuCl2(i-nic)4] as free radical scavengers

AU - Creczynski-Pasa, Tânia B.

AU - Bonetti, Vilson R.

AU - Beirith, Alessandra

AU - Ckless, Karina

AU - Konzen, Marlon

AU - Seifriz, Ilana

AU - Paula, Marcos S.

AU - Franco, Cesar V.

AU - Wilhelm Filho, Danilo Wilhelm

AU - Calixto, João B.

PY - 2001

Y1 - 2001

N2 - This study evaluates the action of the new ruthenium complexes trans-RuCl2(nic)4] (I) and trans-[RuCl2(i-nic)4] (II) as free radical scavengers. In our experiments, both compounds acted as scavengers of superoxide anion (O2˙−), hydroxyl radicals (HO˙) and nitrogen monoxide (formally known as 'nitric oxide'; NO˙). In addition, complexes I and II potentiated the release of NO˙ from S-nitroso-N-acetyl-DL-penicilamine (SNAP), a NO˙ donor. Complex II, but not I, also decreased the nitrite levels in culture media of activated macrophages. A hypsochromic shift of λmax and a significant change in half-wave potential (E1/2) was observed when NO˙ was added to the Complex II. Thiobarbituric reactive substance (TBARS) levels were significantly reduced in rats treated for 1 week with Complex II plus tert-butylhydroperoxide, when compared to rats treated only with tert-butylhydroperoxide. None of the complexes showed cytotoxicity. These findings support the suggestion that the new ruthenium complexes, especially trans-[RuCl2(i-nic)4] or its derivatives, might provide potential therapeutic benefits in disorders where reactive nitrogen (RNS) or oxygen (ROS) species are involved.

AB - This study evaluates the action of the new ruthenium complexes trans-RuCl2(nic)4] (I) and trans-[RuCl2(i-nic)4] (II) as free radical scavengers. In our experiments, both compounds acted as scavengers of superoxide anion (O2˙−), hydroxyl radicals (HO˙) and nitrogen monoxide (formally known as 'nitric oxide'; NO˙). In addition, complexes I and II potentiated the release of NO˙ from S-nitroso-N-acetyl-DL-penicilamine (SNAP), a NO˙ donor. Complex II, but not I, also decreased the nitrite levels in culture media of activated macrophages. A hypsochromic shift of λmax and a significant change in half-wave potential (E1/2) was observed when NO˙ was added to the Complex II. Thiobarbituric reactive substance (TBARS) levels were significantly reduced in rats treated for 1 week with Complex II plus tert-butylhydroperoxide, when compared to rats treated only with tert-butylhydroperoxide. None of the complexes showed cytotoxicity. These findings support the suggestion that the new ruthenium complexes, especially trans-[RuCl2(i-nic)4] or its derivatives, might provide potential therapeutic benefits in disorders where reactive nitrogen (RNS) or oxygen (ROS) species are involved.

KW - Antioxidant

KW - Free radical scavenger

KW - Hydroxyl radical

KW - Nitric oxide

KW - Nitrogen monoxide

KW - Ruthenium complex

KW - Superoxide anion radical

UR - https://www.scopus.com/pages/publications/0034837265

U2 - 10.1016/S0162-0134(01)00222-7

DO - 10.1016/S0162-0134(01)00222-7

M3 - Article

C2 - 11566331

SN - 0162-0134

VL - 86

SP - 587

EP - 594

JO - Journal of Inorganic Biochemistry

JF - Journal of Inorganic Biochemistry

IS - 2-3

ER -

Complexes trans-[RuCl₂(nic)₄] and trans-[RuCl₂(i-nic)₄] as free radical scavengers

Abstract

Keywords

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