Computer-guided design in molecular recognition: Design and synthesis of a glucopyranose receptor

Wei Yang; Huan He; Dale G. Drueckhammer

doi:10.1002/1521-3773(20010504)40:9

Computer-guided design in molecular recognition: Design and synthesis of a glucopyranose receptor

Wei Yang
, Huan He
, Dale G. Drueckhammer

Chemistry

Stony Brook University

Stony Brook University

Research output: Contribution to journal › Article › peer-review

224 Scopus citations

Abstract

Greater than 400-fold selectivity for glucose over galactose, mannose, and fructose has been achieved with a receptor designed by the computer program CAVEAT. The receptor has precisely positioned boronic acid groups of α-D-glucopyranose (see picture) and exhibits a 50% decrease in fluorescence upon glucose binding.

Original language	English
Pages (from-to)	1714-1718
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	40
Issue number	9
DOIs	https://doi.org/10.1002/1521-3773(20010504)40:9
State	Published - May 4 2001

Keywords

Boron
Molecular modeling
Molecular recognition
Receptors
Sensors

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10.1002/1521-3773(20010504)40:9

Cite this

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title = "Computer-guided design in molecular recognition: Design and synthesis of a glucopyranose receptor",

abstract = "Greater than 400-fold selectivity for glucose over galactose, mannose, and fructose has been achieved with a receptor designed by the computer program CAVEAT. The receptor has precisely positioned boronic acid groups of α-D-glucopyranose (see picture) and exhibits a 50\% decrease in fluorescence upon glucose binding.",

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AU - Yang, Wei

AU - He, Huan

AU - Drueckhammer, Dale G.

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Y1 - 2001/5/4

N2 - Greater than 400-fold selectivity for glucose over galactose, mannose, and fructose has been achieved with a receptor designed by the computer program CAVEAT. The receptor has precisely positioned boronic acid groups of α-D-glucopyranose (see picture) and exhibits a 50% decrease in fluorescence upon glucose binding.

AB - Greater than 400-fold selectivity for glucose over galactose, mannose, and fructose has been achieved with a receptor designed by the computer program CAVEAT. The receptor has precisely positioned boronic acid groups of α-D-glucopyranose (see picture) and exhibits a 50% decrease in fluorescence upon glucose binding.

KW - Boron

KW - Molecular modeling

KW - Molecular recognition

KW - Receptors

KW - Sensors

UR - https://www.scopus.com/pages/publications/0035805381

U2 - 10.1002/1521-3773(20010504)40:9

DO - 10.1002/1521-3773(20010504)40:9

M3 - Article

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JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 9

ER -

Computer-guided design in molecular recognition: Design and synthesis of a glucopyranose receptor

Abstract

Keywords

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