TY - GEN
T1 - Consistent detection of cancer biomarkers with linear models
AU - Rivera, E. M.
AU - Irizarry, Z.
AU - Sánchez-Peña, M. L.
AU - Isaza, C. E.
AU - Seguel, J.
AU - Cabrera-Ríos, M.
PY - 2011
Y1 - 2011
N2 - High throughput biological experiments such as DNA Microarrays are very powerful tools to understand and characterize multiple illnesses. These types of experiments, however, have also been described as large, complex, expensive and hard to analyze. For these reasons, analyses with linear assumptions are frequently bypassed for more sophisticated procedures with higher complexity. In this work, a search procedure for potential biomarkers using data from microarray experiments is proposed under purely linear assumptions. The method shows a high discrimination rate and does not require the adjustment of parameters by the user, thus preserving analysis objectivity and repeatability. A case study in the identification of potential biomarkers for cervix cancer is presented to illustrate the application of the proposed procedure.
AB - High throughput biological experiments such as DNA Microarrays are very powerful tools to understand and characterize multiple illnesses. These types of experiments, however, have also been described as large, complex, expensive and hard to analyze. For these reasons, analyses with linear assumptions are frequently bypassed for more sophisticated procedures with higher complexity. In this work, a search procedure for potential biomarkers using data from microarray experiments is proposed under purely linear assumptions. The method shows a high discrimination rate and does not require the adjustment of parameters by the user, thus preserving analysis objectivity and repeatability. A case study in the identification of potential biomarkers for cervix cancer is presented to illustrate the application of the proposed procedure.
KW - Cancer biomarkers
KW - Microarray Experiments
UR - https://www.scopus.com/pages/publications/84855987573
U2 - 10.1109/BIBMW.2011.6112373
DO - 10.1109/BIBMW.2011.6112373
M3 - Conference contribution
SN - 9781457716133
T3 - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
SP - 186
EP - 192
BT - 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2011
T2 - 2011 IEEE International Conference onBioinformatics and Biomedicine Workshops, BIBMW 2011
Y2 - 12 November 2011 through 15 November 2011
ER -