Constriction and coordinated arteriolar network flow behavior with interstitial low dose dilators

Randall Fox; Mary Frame

Constriction and coordinated arteriolar network flow behavior with interstitial low dose dilators

Randall Fox
, Mary Frame

Dept of Biomedical Engineering

Stony Brook University

University of Rochester

Research output: Contribution to journal › Conference article › peer-review

Abstract

Our purpose was to determine whether physiological doses of interstitial adenosine (ADO) or nitric oxide (NP) induced coordinated flow patterns in arteriolar networks. Arteriolar diameter and red cell (RBC) flux were obtained in the check pouch of anesthetized (pentobarbital 70mg/kg) hamster (N = 18). Observations were made along an arteriolar network (feed and 4 branches) during baseline and with 10-9 - 10-5 M ADO or NP (5 min); controls showed steady changes with 5-20 min exposure. In general, changes within the network never predicted the resulting flow patterns, yet at low doses, flux and WSS were coordinated.

Original language	English
Pages (from-to)	S-72
Journal	Annals of Biomedical Engineering
Volume	28
Issue number	SUPPL. 1
State	Published - 2000
Event	2000 Annual Fall Meeting of the Biomedical Engineering Society - Washington, WA, USA Duration: Oct 12 2000 → Oct 14 2000

Cite this

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title = "Constriction and coordinated arteriolar network flow behavior with interstitial low dose dilators",

abstract = "Our purpose was to determine whether physiological doses of interstitial adenosine (ADO) or nitric oxide (NP) induced coordinated flow patterns in arteriolar networks. Arteriolar diameter and red cell (RBC) flux were obtained in the check pouch of anesthetized (pentobarbital 70mg/kg) hamster (N = 18). Observations were made along an arteriolar network (feed and 4 branches) during baseline and with 10-9 - 10-5 M ADO or NP (5 min); controls showed steady changes with 5-20 min exposure. In general, changes within the network never predicted the resulting flow patterns, yet at low doses, flux and WSS were coordinated.",

author = "Randall Fox and Mary Frame",

year = "2000",

language = "English",

volume = "28",

pages = "S--72",

journal = "Annals of Biomedical Engineering",

issn = "0090-6964",

publisher = "Springer",

number = "SUPPL. 1",

note = "2000 Annual Fall Meeting of the Biomedical Engineering Society ; Conference date: 12-10-2000 Through 14-10-2000",

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TY - JOUR

T1 - Constriction and coordinated arteriolar network flow behavior with interstitial low dose dilators

AU - Fox, Randall

AU - Frame, Mary

PY - 2000

Y1 - 2000

N2 - Our purpose was to determine whether physiological doses of interstitial adenosine (ADO) or nitric oxide (NP) induced coordinated flow patterns in arteriolar networks. Arteriolar diameter and red cell (RBC) flux were obtained in the check pouch of anesthetized (pentobarbital 70mg/kg) hamster (N = 18). Observations were made along an arteriolar network (feed and 4 branches) during baseline and with 10-9 - 10-5 M ADO or NP (5 min); controls showed steady changes with 5-20 min exposure. In general, changes within the network never predicted the resulting flow patterns, yet at low doses, flux and WSS were coordinated.

AB - Our purpose was to determine whether physiological doses of interstitial adenosine (ADO) or nitric oxide (NP) induced coordinated flow patterns in arteriolar networks. Arteriolar diameter and red cell (RBC) flux were obtained in the check pouch of anesthetized (pentobarbital 70mg/kg) hamster (N = 18). Observations were made along an arteriolar network (feed and 4 branches) during baseline and with 10-9 - 10-5 M ADO or NP (5 min); controls showed steady changes with 5-20 min exposure. In general, changes within the network never predicted the resulting flow patterns, yet at low doses, flux and WSS were coordinated.

UR - https://www.scopus.com/pages/publications/0034508320

M3 - Conference article

SN - 0090-6964

VL - 28

SP - S-72

JO - Annals of Biomedical Engineering

JF - Annals of Biomedical Engineering

IS - SUPPL. 1

T2 - 2000 Annual Fall Meeting of the Biomedical Engineering Society

Y2 - 12 October 2000 through 14 October 2000

ER -

Constriction and coordinated arteriolar network flow behavior with interstitial low dose dilators

Abstract

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