Contribution of GABA B receptor-mediated inhibition to the expression and termination of group I mGluR-induced ictaform bursts

Péter Huszár; Lisa R. Merlin

doi:10.1016/j.eplepsyres.2004.07.008

Contribution of GABA _B receptor-mediated inhibition to the expression and termination of group I mGluR-induced ictaform bursts

Péter Huszár
, Lisa R. Merlin

Neurology

SUNY Downstate Health Sciences University

SUNY Downstate Health Sciences University

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

In guinea pig hippocampal slices, the GABA _B receptor antagonist CGP 35348 increased the length of picrotoxin-induced interictal bursts by only 22%, yet it increased the length of group I mGluR-induced ictaform bursts by 85%. These data suggest that (1) suppression of GABAergic inhibition is insufficient to account for group I mGluR agonist-induced ictaform bursts, and (2) although GABA _B plays a minor role in terminating interictal bursts, it is a major contributor to the termination of mGluR-induced ictaform bursts.

Original language	English
Pages (from-to)	161-165
Number of pages	5
Journal	Epilepsy Research
Volume	61
Issue number	1-3
DOIs	https://doi.org/10.1016/j.eplepsyres.2004.07.008
State	Published - Sep 2004

Keywords

DHPG
GABA receptor
Group I mGluR
Hippocampal slice
Ictal
Interictal

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10.1016/j.eplepsyres.2004.07.008

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title = "Contribution of GABA B receptor-mediated inhibition to the expression and termination of group I mGluR-induced ictaform bursts",

abstract = "In guinea pig hippocampal slices, the GABA B receptor antagonist CGP 35348 increased the length of picrotoxin-induced interictal bursts by only 22\%, yet it increased the length of group I mGluR-induced ictaform bursts by 85\%. These data suggest that (1) suppression of GABAergic inhibition is insufficient to account for group I mGluR agonist-induced ictaform bursts, and (2) although GABA B plays a minor role in terminating interictal bursts, it is a major contributor to the termination of mGluR-induced ictaform bursts.",

keywords = "DHPG, GABA receptor, Group I mGluR, Hippocampal slice, Ictal, Interictal",

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T1 - Contribution of GABA B receptor-mediated inhibition to the expression and termination of group I mGluR-induced ictaform bursts

AU - Huszár, Péter

AU - Merlin, Lisa R.

PY - 2004/9

Y1 - 2004/9

N2 - In guinea pig hippocampal slices, the GABA B receptor antagonist CGP 35348 increased the length of picrotoxin-induced interictal bursts by only 22%, yet it increased the length of group I mGluR-induced ictaform bursts by 85%. These data suggest that (1) suppression of GABAergic inhibition is insufficient to account for group I mGluR agonist-induced ictaform bursts, and (2) although GABA B plays a minor role in terminating interictal bursts, it is a major contributor to the termination of mGluR-induced ictaform bursts.

AB - In guinea pig hippocampal slices, the GABA B receptor antagonist CGP 35348 increased the length of picrotoxin-induced interictal bursts by only 22%, yet it increased the length of group I mGluR-induced ictaform bursts by 85%. These data suggest that (1) suppression of GABAergic inhibition is insufficient to account for group I mGluR agonist-induced ictaform bursts, and (2) although GABA B plays a minor role in terminating interictal bursts, it is a major contributor to the termination of mGluR-induced ictaform bursts.

KW - DHPG

KW - GABA receptor

KW - Group I mGluR

KW - Hippocampal slice

KW - Ictal

KW - Interictal

UR - https://www.scopus.com/pages/publications/4644371543

U2 - 10.1016/j.eplepsyres.2004.07.008

DO - 10.1016/j.eplepsyres.2004.07.008

M3 - Article

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SN - 0920-1211

VL - 61

SP - 161

EP - 165

JO - Epilepsy Research

JF - Epilepsy Research

IS - 1-3

ER -

Contribution of GABA _B receptor-mediated inhibition to the expression and termination of group I mGluR-induced ictaform bursts

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