Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition

Yizhong Wang; Claudia I. Rivera Vera; Qing Lin

doi:10.1021/ol7017328

Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition

Yizhong Wang
, Claudia I. Rivera Vera
, Qing Lin

Chemistry

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

162 Scopus citations

Abstract

A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regiosetectivity, and yield.

Original language	English
Pages (from-to)	4155-4158
Number of pages	4
Journal	Organic Letters
Volume	9
Issue number	21
DOIs	https://doi.org/10.1021/ol7017328
State	Published - Oct 11 2007

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10.1021/ol7017328

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title = "Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition",

abstract = "A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regiosetectivity, and yield.",

author = "Yizhong Wang and \{Rivera Vera\}, \{Claudia I.\} and Qing Lin",

year = "2007",

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doi = "10.1021/ol7017328",

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journal = "Organic Letters",

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AU - Wang, Yizhong

AU - Rivera Vera, Claudia I.

AU - Lin, Qing

PY - 2007/10/11

Y1 - 2007/10/11

N2 - A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regiosetectivity, and yield.

AB - A mild, photoactivated 1,3-dipolar cycloaddition procedure was successfully developed for the synthesis of polysubstituted pyrazolines. This procedure involved the in situ generation of the reactive nitrile imine dipoles using a hand-held UV lamp at 302 nm, followed by spontaneous cycloaddition with a broad range of 1,3-dipolarophiles with excellent solvent compatibility, functional group tolerance, regiosetectivity, and yield.

UR - https://www.scopus.com/pages/publications/35548939994

U2 - 10.1021/ol7017328

DO - 10.1021/ol7017328

M3 - Article

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SN - 1523-7060

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SP - 4155

EP - 4158

JO - Organic Letters

JF - Organic Letters

IS - 21

ER -

Convenient synthesis of highly functionalized pyrazolines via mild, photoactivated 1,3-dipolar cycloaddition

Abstract

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