Coordination-driven self-assembly of ruthenium-based molecular-rectangles: Synthesis, characterization, photo-physical and anticancer potency studies

Vaishali Vajpayee; Young Ho Song; Young Jun Jung; Se Chan Kang; Hyunuk Kim; In Su Kim; Ming Wang; Timothy R. Cook; Peter J. Stang; Ki Whan Chi

doi:10.1039/c2dt11811d

Coordination-driven self-assembly of ruthenium-based molecular-rectangles: Synthesis, characterization, photo-physical and anticancer potency studies

Vaishali Vajpayee
, Young Ho Song
, Young Jun Jung
, Se Chan Kang
, Hyunuk Kim
, In Su Kim
, Ming Wang
, Timothy R. Cook
, Peter J. Stang
, Ki Whan Chi

Chemistry

University at Buffalo

University of Ulsan
University of Semyung
Pohang University of Science and Technology
University of Utah

Research output: Contribution to journal › Article › peer-review

61 Scopus citations

Abstract

A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92%) rectangles were characterized by ¹H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC ₅₀ values comparable to those of cisplatin and doxorubicin.

Original language	English
Pages (from-to)	3046-3052
Number of pages	7
Journal	Dalton Transactions
Volume	41
Issue number	10
DOIs	https://doi.org/10.1039/c2dt11811d
State	Published - Mar 14 2012

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title = "Coordination-driven self-assembly of ruthenium-based molecular-rectangles: Synthesis, characterization, photo-physical and anticancer potency studies",

abstract = "A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92\%) rectangles were characterized by 1H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC 50 values comparable to those of cisplatin and doxorubicin.",

author = "Vaishali Vajpayee and Song, \{Young Ho\} and Jung, \{Young Jun\} and Kang, \{Se Chan\} and Hyunuk Kim and Kim, \{In Su\} and Ming Wang and Cook, \{Timothy R.\} and Stang, \{Peter J.\} and Chi, \{Ki Whan\}",

year = "2012",

month = mar,

day = "14",

doi = "10.1039/c2dt11811d",

language = "English",

volume = "41",

pages = "3046--3052",

journal = "Dalton Transactions",

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T1 - Coordination-driven self-assembly of ruthenium-based molecular-rectangles

T2 - Synthesis, characterization, photo-physical and anticancer potency studies

AU - Vajpayee, Vaishali

AU - Song, Young Ho

AU - Jung, Young Jun

AU - Kang, Se Chan

AU - Kim, Hyunuk

AU - Kim, In Su

AU - Wang, Ming

AU - Cook, Timothy R.

AU - Stang, Peter J.

AU - Chi, Ki Whan

PY - 2012/3/14

Y1 - 2012/3/14

N2 - A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92%) rectangles were characterized by 1H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC 50 values comparable to those of cisplatin and doxorubicin.

AB - A suite of eight cationic, tetra-metallic molecular rectangles (1-8) was generated via coordination-driven self-assembly using four dicarboxylate-bridged arene-Ru precursors (A1-A4) with one of two dipyridyl ligands (D1, D2). The high-yielding (84-92%) rectangles were characterized by 1H NMR and HR-ESI-MS to support their structural assignments. The molecular structure of 5 was determined by single crystal X-ray analysis, which indicated that two D2 ligands bridge two A1 acceptors to form a rectangular construct. The photophysical properties of these metalla-rectangles and their molecular precursors were also investigated, as well as an MTT assay to evaluate the in vitro cytotoxicities relative to two chemotherapeutic agents, cisplatin and doxorubicin. MTT assays were conducted using SK-hep-1 (liver cancer) and HCT-15 (colon cancer) human cancer cell lines. Compounds 3, 4, 7 and 8 showed significant activity, with IC 50 values comparable to those of cisplatin and doxorubicin.

UR - https://www.scopus.com/pages/publications/84863115933

U2 - 10.1039/c2dt11811d

DO - 10.1039/c2dt11811d

M3 - Article

C2 - 22278716

SN - 1477-9226

VL - 41

SP - 3046

EP - 3052

JO - Dalton Transactions

JF - Dalton Transactions

IS - 10

ER -

Coordination-driven self-assembly of ruthenium-based molecular-rectangles: Synthesis, characterization, photo-physical and anticancer potency studies

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