Degradation kinetics of imipenem in normal saline and in human serum

D. J. Swanson; C. DeAngelis; I. L. Smith; J. J. Schentag

doi:10.1128/AAC.29.5.936

Degradation kinetics of imipenem in normal saline and in human serum

D. J. Swanson
, C. DeAngelis
, I. L. Smith
, J. J. Schentag

Pharmacy

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

29 Scopus citations

Abstract

The stability of imipenem in 0.9% sodium chloride and in human serum was measured at controlled temperatures over time. The degradation was characterized by a first-order process and was consistent with an apparent hydrolysis reaction.

Original language	English
Pages (from-to)	936-937
Number of pages	2
Journal	Antimicrobial Agents and Chemotherapy
Volume	29
Issue number	5
DOIs	https://doi.org/10.1128/AAC.29.5.936
State	Published - 1986

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title = "Degradation kinetics of imipenem in normal saline and in human serum",

abstract = "The stability of imipenem in 0.9\% sodium chloride and in human serum was measured at controlled temperatures over time. The degradation was characterized by a first-order process and was consistent with an apparent hydrolysis reaction.",

author = "Swanson, \{D. J.\} and C. DeAngelis and Smith, \{I. L.\} and Schentag, \{J. J.\}",

year = "1986",

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language = "English",

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T1 - Degradation kinetics of imipenem in normal saline and in human serum

AU - Swanson, D. J.

AU - DeAngelis, C.

AU - Smith, I. L.

AU - Schentag, J. J.

PY - 1986

Y1 - 1986

N2 - The stability of imipenem in 0.9% sodium chloride and in human serum was measured at controlled temperatures over time. The degradation was characterized by a first-order process and was consistent with an apparent hydrolysis reaction.

AB - The stability of imipenem in 0.9% sodium chloride and in human serum was measured at controlled temperatures over time. The degradation was characterized by a first-order process and was consistent with an apparent hydrolysis reaction.

UR - https://www.scopus.com/pages/publications/0022639511

U2 - 10.1128/AAC.29.5.936

DO - 10.1128/AAC.29.5.936

M3 - Article

C2 - 3460525

SN - 0066-4804

VL - 29

SP - 936

EP - 937

JO - Antimicrobial Agents and Chemotherapy

JF - Antimicrobial Agents and Chemotherapy

IS - 5

ER -

Degradation kinetics of imipenem in normal saline and in human serum

Abstract

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