Design and synthesis of 3,5-dialkylamino substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2 -g]pteridine-7-ones

Ping Ge; Thomas I. Kalman

doi:10.1016/S0960-894X(97)10138-X

Design and synthesis of 3,5-dialkylamino substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2 -g]pteridine-7-ones

Ping Ge
, Thomas I. Kalman

Chemistry

University at Buffalo

SUNY Buffalo

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

3,5-Dialkylamino substituted 8H,10H,15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2-g]pteridine -7-one derivatives 6a-6e were synthesized as potential anticancer agents. Preliminary results showed that they were active as inhibitors of the growth of murine leukemia L1210 cells in vitro with IC₅₀-values of 4 to 24 μM.

Original language	English
Pages (from-to)	3023-3026
Number of pages	4
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	7
Issue number	23
DOIs	https://doi.org/10.1016/S0960-894X(97)10138-X
State	Published - Dec 2 1997

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10.1016/S0960-894X(97)10138-X

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@article{9da16e086c4340c2bd1b257eaaa775af,

title = "Design and synthesis of 3,5-dialkylamino substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2 -g]pteridine-7-ones",

abstract = "3,5-Dialkylamino substituted 8H,10H,15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2-g]pteridine -7-one derivatives 6a-6e were synthesized as potential anticancer agents. Preliminary results showed that they were active as inhibitors of the growth of murine leukemia L1210 cells in vitro with IC50-values of 4 to 24 μM.",

author = "Ping Ge and Kalman, \{Thomas I.\}",

year = "1997",

month = dec,

day = "2",

doi = "10.1016/S0960-894X(97)10138-X",

language = "English",

volume = "7",

pages = "3023--3026",

journal = "Bioorganic and Medicinal Chemistry Letters",

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number = "23",

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TY - JOUR

T1 - Design and synthesis of 3,5-dialkylamino substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2 -g]pteridine-7-ones

AU - Ge, Ping

AU - Kalman, Thomas I.

PY - 1997/12/2

Y1 - 1997/12/2

N2 - 3,5-Dialkylamino substituted 8H,10H,15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2-g]pteridine -7-one derivatives 6a-6e were synthesized as potential anticancer agents. Preliminary results showed that they were active as inhibitors of the growth of murine leukemia L1210 cells in vitro with IC50-values of 4 to 24 μM.

AB - 3,5-Dialkylamino substituted 8H,10H,15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2-g]pteridine -7-one derivatives 6a-6e were synthesized as potential anticancer agents. Preliminary results showed that they were active as inhibitors of the growth of murine leukemia L1210 cells in vitro with IC50-values of 4 to 24 μM.

UR - https://www.scopus.com/pages/publications/0030662589

U2 - 10.1016/S0960-894X(97)10138-X

DO - 10.1016/S0960-894X(97)10138-X

M3 - Article

SN - 0960-894X

VL - 7

SP - 3023

EP - 3026

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

IS - 23

ER -

Design and synthesis of 3,5-dialkylamino substituted 8H,10H-3(R),5(R),15b(S)-2,3,6,7-tetrahydro-1,5,3-dioxazepino[3,2-c]indolo[3,2 -g]pteridine-7-ones

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