Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation

Thota Ganesh; Andrew Norris; Shubhada Sharma; Susan Bane; Ana A. Alcaraz; James P. Snyder; David G.I. Kingston

doi:10.1016/j.bmc.2006.01.002

Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation

Thota Ganesh
, Andrew Norris
, Shubhada Sharma
, Susan Bane
, Ana A. Alcaraz
, James P. Snyder
, David G.I. Kingston

Chemistry

Binghamton University

Research output: Contribution to journal › Article › peer-review

45 Scopus citations

Abstract

A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself.

Original language	English
Pages (from-to)	3447-3454
Number of pages	8
Journal	Bioorganic and Medicinal Chemistry
Volume	14
Issue number	10
DOIs	https://doi.org/10.1016/j.bmc.2006.01.002
State	Published - May 15 2006

Keywords

Cytotoxicity
Molecular modeling
Olefin metathesis
Paclitaxel
Synthesis
Taxol
Tubulin

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10.1016/j.bmc.2006.01.002

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abstract = "A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself.",

keywords = "Cytotoxicity, Molecular modeling, Olefin metathesis, Paclitaxel, Synthesis, Taxol, Tubulin",

author = "Thota Ganesh and Andrew Norris and Shubhada Sharma and Susan Bane and Alcaraz, \{Ana A.\} and Snyder, \{James P.\} and Kingston, \{David G.I.\}",

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AU - Ganesh, Thota

AU - Norris, Andrew

AU - Sharma, Shubhada

AU - Bane, Susan

AU - Alcaraz, Ana A.

AU - Snyder, James P.

AU - Kingston, David G.I.

PY - 2006/5/15

Y1 - 2006/5/15

N2 - A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself.

AB - A strategy for the design and synthesis of simplified paclitaxel analogs based on the T-Taxol conformation is presented. The resulting compounds have both cytotoxic and tubulin polymerization activities, although less so than those of paclitaxel itself.

KW - Cytotoxicity

KW - Molecular modeling

KW - Olefin metathesis

KW - Paclitaxel

KW - Synthesis

KW - Taxol

KW - Tubulin

UR - https://www.scopus.com/pages/publications/33645858789

U2 - 10.1016/j.bmc.2006.01.002

DO - 10.1016/j.bmc.2006.01.002

M3 - Article

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VL - 14

SP - 3447

EP - 3454

JO - Bioorganic and Medicinal Chemistry

JF - Bioorganic and Medicinal Chemistry

IS - 10

ER -

Design, synthesis, and bioactivity of simplified paclitaxel analogs based on the T-Taxol bioactive conformation

Abstract

Keywords

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