Designing RNA structures: Natural and artificial selection

Barry Cohen; Steven Skiena

Designing RNA structures: Natural and artificial selection

Barry Cohen
, Steven Skiena

Computer Science

Stony Brook University

New Jersey Institute of Technology

Research output: Contribution to conference › Paper › peer-review

5 Scopus citations

Abstract

Nature has wide latitude to select among messenger RNA (mRNA) sequences which are informationally equivalent, but structurally and energetically divergent. In this work, an attempt is made to explore how nature takes advantage of this freedom, and how to algorithmically design structures more energetically favorable than have been built through natural selection. Experimental results are discussed, placing the high/low stability sequences in context with both wildtype and random encodings.

Original language	English
Pages	109-116
Number of pages	8
State	Published - 2002
Event	RECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology - Washington, DC, United States Duration: Apr 18 2002 → Apr 21 2002

Conference

Conference	RECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology
Country/Territory	United States
City	Washington, DC
Period	04/18/02 → 04/21/02

Cite this

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title = "Designing RNA structures: Natural and artificial selection",

abstract = "Nature has wide latitude to select among messenger RNA (mRNA) sequences which are informationally equivalent, but structurally and energetically divergent. In this work, an attempt is made to explore how nature takes advantage of this freedom, and how to algorithmically design structures more energetically favorable than have been built through natural selection. Experimental results are discussed, placing the high/low stability sequences in context with both wildtype and random encodings.",

author = "Barry Cohen and Steven Skiena",

year = "2002",

language = "English",

pages = "109--116",

note = "RECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology ; Conference date: 18-04-2002 Through 21-04-2002",

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T1 - Designing RNA structures

T2 - RECOMB 2002: Proceedings of the Sixth Annual International Conference on Computational Biology

AU - Cohen, Barry

AU - Skiena, Steven

PY - 2002

Y1 - 2002

N2 - Nature has wide latitude to select among messenger RNA (mRNA) sequences which are informationally equivalent, but structurally and energetically divergent. In this work, an attempt is made to explore how nature takes advantage of this freedom, and how to algorithmically design structures more energetically favorable than have been built through natural selection. Experimental results are discussed, placing the high/low stability sequences in context with both wildtype and random encodings.

AB - Nature has wide latitude to select among messenger RNA (mRNA) sequences which are informationally equivalent, but structurally and energetically divergent. In this work, an attempt is made to explore how nature takes advantage of this freedom, and how to algorithmically design structures more energetically favorable than have been built through natural selection. Experimental results are discussed, placing the high/low stability sequences in context with both wildtype and random encodings.

UR - https://www.scopus.com/pages/publications/0036376063

M3 - Paper

SP - 109

EP - 116

Y2 - 18 April 2002 through 21 April 2002

ER -

Designing RNA structures: Natural and artificial selection

Abstract

Conference

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