@inproceedings{7ab5fc1821764e9e8321eaa01b06c84a,
title = "Detecting functional modules in dynamic protein-protein interaction networks using Markov Clustering and Firefly Algorithm",
abstract = "Markov Clustering (MCL) is a popular algorithm for clustering networks in bioinformatics such as Protein-Protein Interaction (PPI) networks and especially, shows excellent performance in clustering Dynamic Proteinprotein Interaction Networks (DPIN). However, a limitation of MCL and its variants (e.g. regularized MCL and soft regularized MCL) is that the clustering results are mostly dependent on the parameters that user-specified. However we know that different networks with various scales need different parameters. In this article, we propose a new MCL method based on the Firefly Algorithm (FA) to optimize its parameters. The results on DIP dataset show that the new algorithm outperforms the state-of-the-art approaches in terms of accuracy of identifying functional modules on a real DPIN.",
keywords = "Dynamic Protein-Protein Interaction Network (DPIN), Firefly Algorithm (FA), Markov Clustering (MCL) algorithm",
author = "Xiujuan Lei and Wu, \{Fang Xiang\} and Fei Wang and Aidong Zhang",
note = "Publisher Copyright: {\textcopyright} 2014 IEEE.; 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014 ; Conference date: 02-11-2014 Through 05-11-2014",
year = "2014",
month = dec,
day = "29",
doi = "10.1109/BIBM.2014.6999131",
language = "English",
series = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",
publisher = "Institute of Electrical and Electronics Engineers Inc.",
pages = "75--81",
editor = "Huiru Zheng and Hu, \{Xiaohua Tony\} and Daniel Berrar and Yadong Wang and Werner Dubitzky and Jin-Kao Hao and Kwang-Hyun Cho and David Gilbert",
booktitle = "Proceedings - 2014 IEEE International Conference on Bioinformatics and Biomedicine, IEEE BIBM 2014",
address = "United States",
}