TY - GEN
T1 - Detecting thalamic abnormalities in autism using cylinder conformal mapping
AU - He, Qing
AU - Duan, Ye
AU - Yin, Xiaotian
AU - Gu, Xianfeng
AU - Karsch, Kevin
AU - Miles, Judith
PY - 2008
Y1 - 2008
N2 - A number of studies have documented that autism has a neurobiological basis, but the anatomical extent of these neurobiological abnormalities is largely unknown. In this paper, we applied advanced computational techniques to extract 3D surface models of the thalamus and subsequently analyze highly localized shape variations in a homogeneous group of autism children. In particular, a new conformal parameterization for high genus surfaces is applied in our shape analysis work, which maps the surfaces onto a cylinder domain. Surface matching among different individual meshes is achieved by re-triangulating each mesh according to the template. Children with autism and their controls are compared, and statistical significant abnormalities in thalamus of autism are detected.
AB - A number of studies have documented that autism has a neurobiological basis, but the anatomical extent of these neurobiological abnormalities is largely unknown. In this paper, we applied advanced computational techniques to extract 3D surface models of the thalamus and subsequently analyze highly localized shape variations in a homogeneous group of autism children. In particular, a new conformal parameterization for high genus surfaces is applied in our shape analysis work, which maps the surfaces onto a cylinder domain. Surface matching among different individual meshes is achieved by re-triangulating each mesh according to the template. Children with autism and their controls are compared, and statistical significant abnormalities in thalamus of autism are detected.
UR - https://www.scopus.com/pages/publications/70149098950
U2 - 10.1007/978-3-540-89646-3_73
DO - 10.1007/978-3-540-89646-3_73
M3 - Conference contribution
SN - 3540896457
SN - 9783540896456
T3 - Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
SP - 743
EP - 751
BT - Advances in Visual Computing - 4th International Symposium, ISVC 2008, Proceedings
T2 - 4th International Symposium on Visual Computing, ISVC 2008
Y2 - 1 December 2008 through 3 December 2008
ER -